Korean J Hematol 2001; 36(1):
Published online March 31, 2001
© The Korean Society of Hematology
급성 골수성 백혈병 환자에서 화학요법과 비경구적 영양요법 중 발생한 의인성 베르니케 뇌증
홍순홍, 김은수, 노양원, 정성권, 정찬, 공희상, 윤창본, 강성수, 이선규, 황희영, 방수미, 조은경, 신동복, 이재훈
가천대학교 의과대학 부속 길병원 혈액종양내과,
가천대학교 의과대학 부속 길병원 신경과,
가천대학교 의과대학 부속 길병원 진단방사선과
A Case of Iatrogenic Wernicke's Encephalopathy Following Chemotherapy and Total Parenteral Nutrition
Wernicke's encephalopathy is a neuropsychiatric condition generally caused by acute thiamine deficiency. Although it is common in the severe alcoholics, several other causes also have been identified, such as total parenteral nutrition (TPN) use,
persistent vomiting, hyperemesis gravidarum, anorexia nervosa and malnutrition. The classic triad of Wernicke's encephalopathy are ataxia, altered mentation and ophthalmoplegia. A 19-year-old boy had been treated with high dose Ara-C and
mitoxantrone
for acute myelogenous leukemia and intravenous hyperalimentation due to persistent vomiting. He suddenly complained of diplopia, gait disturbance and generalized weakness at 36th day after chemotherapy. Physical examinations showed disorientated
mentality, oculomotor palsy and horizental nystagmus. The diagnosis of Wernicke's encephalopathy was made with classical brain MRI and decreased thiamine level. The patient was successfully treated with vitamin B1. We presented a case of acute
Wernicke's encephalopathy developed after high dose Ara-C chemotherapy followed by intravenous hyperalimentation in a patient with acute myelogenous leukemia.
Keywords Wernicke's encephalopathy; Thiamine deficiency; AML; Chemotherapy; Parenteral nutrition;
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Korean J Hematol 2001; 36(1): 95-99
Published online March 31, 2001
Copyright © The Korean Society of Hematology.
급성 골수성 백혈병 환자에서 화학요법과 비경구적 영양요법 중 발생한 의인성 베르니케 뇌증
홍순홍, 김은수, 노양원, 정성권, 정찬, 공희상, 윤창본, 강성수, 이선규, 황희영, 방수미, 조은경, 신동복, 이재훈
가천대학교 의과대학 부속 길병원 혈액종양내과,
가천대학교 의과대학 부속 길병원 신경과,
가천대학교 의과대학 부속 길병원 진단방사선과
A Case of Iatrogenic Wernicke's Encephalopathy Following Chemotherapy and Total Parenteral Nutrition
Soon Hong Hong, Eun Soo Kim, Yang Won Roh, Sung Kueon Jung, Chan Chung, Hee Sang Kong, Chang Bon Yun, Sung Soo Kang, Seon Kyu Lee, Hee Young Hwang, Soo Mee Bang, Eun Kyung Cho, Dong Bok Shin, Ja
Department of Internal Medicine, Neurology, Gachon Medical School, Gil Medical Center, Inchon, Korea
Abstract
Wernicke's encephalopathy is a neuropsychiatric condition generally caused by acute thiamine deficiency. Although it is common in the severe alcoholics, several other causes also have been identified, such as total parenteral nutrition (TPN) use,
persistent vomiting, hyperemesis gravidarum, anorexia nervosa and malnutrition. The classic triad of Wernicke's encephalopathy are ataxia, altered mentation and ophthalmoplegia. A 19-year-old boy had been treated with high dose Ara-C and
mitoxantrone
for acute myelogenous leukemia and intravenous hyperalimentation due to persistent vomiting. He suddenly complained of diplopia, gait disturbance and generalized weakness at 36th day after chemotherapy. Physical examinations showed disorientated
mentality, oculomotor palsy and horizental nystagmus. The diagnosis of Wernicke's encephalopathy was made with classical brain MRI and decreased thiamine level. The patient was successfully treated with vitamin B1. We presented a case of acute
Wernicke's encephalopathy developed after high dose Ara-C chemotherapy followed by intravenous hyperalimentation in a patient with acute myelogenous leukemia.
Keywords: Wernicke's encephalopathy, Thiamine deficiency, AML, Chemotherapy, Parenteral nutrition,
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