Korean J Hematol 1999; 34(4):
Published online December 31, 1999
© The Korean Society of Hematology
박재완, 안인섭, 정소영, 오도연, 강명서, 이용희
포천중문 의과대학 내과학교실,
포천중문 의과대학 임상병리학교실,
포천중문 의과대학 해부병리학교실
The prognosis of invasive aspergillosis in allogeneic bone marrow transplantation recipients is grave in the absence of bone marrow recovery in spite of antifungal treatment with amphotericin B. Beneficial role of granulocyte transfusion in neutropenic patients with fungal infection has been re-evaluated since granulocyte colony-stimulating factor made effective collection of granulocyte possible. And Liposomal amphotericin appears to be an effective alternative to conventional amphotericin B with much less toxicity. A 34-year-old patient with acute lymphoblastic leukemia developed invasive pulmonary aspergillosis during very early period of allogeneic hemopoietic stem cell transplantation. We treated the case successfully with liposomal amphotericin and granulocyte transfusion and surgery in spite of known high mortality of invasive aspergillosis in transplantation patients.
Keywords Invasive aspergillosis, Granulocyte transfusion, Liposomal amphotericin, Leukemia, Allogeneic hemopoietic stem cell transplantation
Korean J Hematol 1999; 34(4): 625-629
Published online December 31, 1999
Copyright © The Korean Society of Hematology.
박재완, 안인섭, 정소영, 오도연, 강명서, 이용희
포천중문 의과대학 내과학교실,
포천중문 의과대학 임상병리학교실,
포천중문 의과대학 해부병리학교실
Jae Wan Park, Ihn Sub Ahn, So Young Chong, Do Yeun Oh, Myung Seo Kang, Yong Hee Lee
Department of Internal Medicine, Clinical Pathology, Anatomical Pathology, College of Medicine, Pochon CHA University, Pochon, Korea
The prognosis of invasive aspergillosis in allogeneic bone marrow transplantation recipients is grave in the absence of bone marrow recovery in spite of antifungal treatment with amphotericin B. Beneficial role of granulocyte transfusion in neutropenic patients with fungal infection has been re-evaluated since granulocyte colony-stimulating factor made effective collection of granulocyte possible. And Liposomal amphotericin appears to be an effective alternative to conventional amphotericin B with much less toxicity. A 34-year-old patient with acute lymphoblastic leukemia developed invasive pulmonary aspergillosis during very early period of allogeneic hemopoietic stem cell transplantation. We treated the case successfully with liposomal amphotericin and granulocyte transfusion and surgery in spite of known high mortality of invasive aspergillosis in transplantation patients.
Keywords: Invasive aspergillosis, Granulocyte transfusion, Liposomal amphotericin, Leukemia, Allogeneic hemopoietic stem cell transplantation
Young‑Uk Cho
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