Korean J Hematol 1999; 34(4):

Published online December 31, 1999

© The Korean Society of Hematology

Liposomal Amphotericin, 과립구 수혈 및 수술로 완치된 동종 조혈모세포 이식중 발생한 침습성 폐 아스페르길루스증 1례

박재완, 안인섭, 정소영, 오도연, 강명서, 이용희

포천중문 의과대학 내과학교실,
포천중문 의과대학 임상병리학교실,
포천중문 의과대학 해부병리학교실

A Case of Invasive Pulmonary Aspergillosis Cured with Liposomal Amphotericin, Granulocyte Transfusion and Surgery in on Allogeneic Hemopoietic Stem Cell Transplantation Recipient

Jae Wan Park, Ihn Sub Ahn, So Young Chong, Do Yeun Oh, Myung Seo Kang, Yong Hee Lee

Department of Internal Medicine, Clinical Pathology, Anatomical Pathology, College of Medicine, Pochon CHA University, Pochon, Korea

Abstract

The prognosis of invasive aspergillosis in allogeneic bone marrow transplantation recipients is grave in the absence of bone marrow recovery in spite of antifungal treatment with amphotericin B. Beneficial role of granulocyte transfusion in neutropenic patients with fungal infection has been re-evaluated since granulocyte colony-stimulating factor made effective collection of granulocyte possible. And Liposomal amphotericin appears to be an effective alternative to conventional amphotericin B with much less toxicity. A 34-year-old patient with acute lymphoblastic leukemia developed invasive pulmonary aspergillosis during very early period of allogeneic hemopoietic stem cell transplantation. We treated the case successfully with liposomal amphotericin and granulocyte transfusion and surgery in spite of known high mortality of invasive aspergillosis in transplantation patients.

Keywords Invasive aspergillosis, Granulocyte transfusion, Liposomal amphotericin, Leukemia, Allogeneic hemopoietic stem cell transplantation

Article

Korean J Hematol 1999; 34(4): 625-629

Published online December 31, 1999

Copyright © The Korean Society of Hematology.

Liposomal Amphotericin, 과립구 수혈 및 수술로 완치된 동종 조혈모세포 이식중 발생한 침습성 폐 아스페르길루스증 1례

박재완, 안인섭, 정소영, 오도연, 강명서, 이용희

포천중문 의과대학 내과학교실,
포천중문 의과대학 임상병리학교실,
포천중문 의과대학 해부병리학교실

A Case of Invasive Pulmonary Aspergillosis Cured with Liposomal Amphotericin, Granulocyte Transfusion and Surgery in on Allogeneic Hemopoietic Stem Cell Transplantation Recipient

Jae Wan Park, Ihn Sub Ahn, So Young Chong, Do Yeun Oh, Myung Seo Kang, Yong Hee Lee

Department of Internal Medicine, Clinical Pathology, Anatomical Pathology, College of Medicine, Pochon CHA University, Pochon, Korea

Abstract

The prognosis of invasive aspergillosis in allogeneic bone marrow transplantation recipients is grave in the absence of bone marrow recovery in spite of antifungal treatment with amphotericin B. Beneficial role of granulocyte transfusion in neutropenic patients with fungal infection has been re-evaluated since granulocyte colony-stimulating factor made effective collection of granulocyte possible. And Liposomal amphotericin appears to be an effective alternative to conventional amphotericin B with much less toxicity. A 34-year-old patient with acute lymphoblastic leukemia developed invasive pulmonary aspergillosis during very early period of allogeneic hemopoietic stem cell transplantation. We treated the case successfully with liposomal amphotericin and granulocyte transfusion and surgery in spite of known high mortality of invasive aspergillosis in transplantation patients.

Keywords: Invasive aspergillosis, Granulocyte transfusion, Liposomal amphotericin, Leukemia, Allogeneic hemopoietic stem cell transplantation

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