Acute febrile neutrophilic dermatosis, also known as 'Sweet's Syndrome', represents a clinical entity of unknown etiology & pathogenesis. Acute febrile neutrophilic dermatosis (Sweet's syndrome) described by Sweet in 1964, consists of multiple tender, red plaques, often accompanied by fever and neutrophilic leukocytosis. Cutaneous biopsy specimens contain dermal infiltrates of mature neutrophil. Response to systemic steroid is dramatic. Sweet's syndrome is reported to be a marker for underlying malignancy. Of the reported cases approximatory 20 percent were associated with malignancy and nearly 10 percent of all reported cases of Sweet's syndrome have been associated tilth acute myelogenous leukemia. We might safely say that a WBC of greater than 25,000/㎕ in any patient with this disease should make one consider the possibility of underlying leukemia or at least the existence of a precursor state. A 68-years-old female patient admitted because of sustained fever and multiple erythematous painful plaques of skin with marked leukocytosis, anemia and thrombocytopenia. Bone marrow revealed acute myelogenous leukemia. Our patient reported a history of recurrent erythematous painful plaque on skin for 8 year in the past. W8 reported a case of
acute febrile neutrophilic dermatosis with underlying acute myelogenous leukemia.

Keywords: Acute myelogenous leukemia, Acute febrile neutrophilic dermatosis