Korean J Hematol 1998; 33(1):
Published online March 31, 1998
© The Korean Society of Hematology
Mantle Cell Lymphoma 1례
-bcl-l/JH 유전자 재배열에 대한 PCR과 cyclin D1에 대한 면역조직화학염색으로 확인된 -
김봉석, 이승숙, 민지영, 강성욱, 류백렬, 김태유, 임영혁, 강윤구
원자력병원 혈액종양내과,
원자력병원 병리과,
원자력병원 실험치료연구실
A Case of Mantle Cell Lymphoma Confirmed with
-bcl-l/JH Rearrangement by PCR and Cyclic D1 Overexpression by Immunohistochemistry-
Mantle cell lymphoma (MCL) is a recently recognized subtype of B-cell non-Hodgkin lymphoma (NHL), which has unique clinical characteristics but is difficult to diagnose on histopathologic criteria. Recently, molecular analysis has shown that MCL has characteristic chromosomal translocation of t (11;14)(q13;q32), which results in bcl-1/JH rearrangement and cyclin D1 overexpression. We experienced a 61-year old woman with MCL, which had relapsed into cervical lymph node enlargement 4 years after complete remission. She again received combination chemotherapy but clinical course was waxed and waned without complete remission. After 3 years from first relapse, she died because of rapid disease progression with massive gastric infiltration and intraabdominal
lymphadenopathy. From the biopsy specimen of cervical lymph nodes we confirmed the bcl-1/JH rearrangement and cyclic Dl overexpression of the tumor by polymerase chain
reaction (PCR) and immunohistochemistry. This might be the first case report of MCL in Korea confirmed with bcl-1/JH gene rearrangement by PCR and cyclin D1 overexpression by immunohistochemistry.
Keywords Mantle cell lymphoma; bcl-1/JH rearrangement; Cyclin D1 overexpression; PCR; Immunohistochemistry;
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Korean J Hematol 1998; 33(1): 138-145
Published online March 31, 1998
Copyright © The Korean Society of Hematology.
Mantle Cell Lymphoma 1례
-bcl-l/JH 유전자 재배열에 대한 PCR과 cyclin D1에 대한 면역조직화학염색으로 확인된 -
김봉석, 이승숙, 민지영, 강성욱, 류백렬, 김태유, 임영혁, 강윤구
원자력병원 혈액종양내과,
원자력병원 병리과,
원자력병원 실험치료연구실
A Case of Mantle Cell Lymphoma Confirmed with
-bcl-l/JH Rearrangement by PCR and Cyclic D1 Overexpression by Immunohistochemistry-
Bong-Seog Kim, Seung, Sook Lee, Jee, Young Min, Sung, Wook Kang, Baek, Yeol Ryoo, Tae You Kim, Young, Hyuck Im, Yoon, Koo Kang
Department of Internal Medicine, Pathology, Laboratory of Experimental Therapeutics, Korea Cancer Hospital, Seoul, Korea
Abstract
Mantle cell lymphoma (MCL) is a recently recognized subtype of B-cell non-Hodgkin lymphoma (NHL), which has unique clinical characteristics but is difficult to diagnose on histopathologic criteria. Recently, molecular analysis has shown that MCL has characteristic chromosomal translocation of t (11;14)(q13;q32), which results in bcl-1/JH rearrangement and cyclin D1 overexpression. We experienced a 61-year old woman with MCL, which had relapsed into cervical lymph node enlargement 4 years after complete remission. She again received combination chemotherapy but clinical course was waxed and waned without complete remission. After 3 years from first relapse, she died because of rapid disease progression with massive gastric infiltration and intraabdominal
lymphadenopathy. From the biopsy specimen of cervical lymph nodes we confirmed the bcl-1/JH rearrangement and cyclic Dl overexpression of the tumor by polymerase chain
reaction (PCR) and immunohistochemistry. This might be the first case report of MCL in Korea confirmed with bcl-1/JH gene rearrangement by PCR and cyclin D1 overexpression by immunohistochemistry.
Keywords: Mantle cell lymphoma, bcl-1/JH rearrangement, Cyclin D1 overexpression, PCR, Immunohistochemistry,
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