Korean J Hematol 1997; 32(3):
Published online September 30, 1997
© The Korean Society of Hematology
Numb chin 증후군을 동반한 악성 혈액 질환 2례
채경수, 지재환, 이정애, 안진석, 우인숙, 박영이, 박영석, 박지영, 조현찬
한림대학교 의과대학 내과학교실,
한림대학교 의과대학 임상병리학교실
Numb Chin Syndrome in Malignant Disease
The numb chin syndrome(NCS) is characterized by chin or lower lip numbness restricted to the distribution of mental nerve(the distal trigeminal nerve). This uncommon neuropathy may be associated with neoplastic disease and usually appeared as a late manifestation of systemic malignancy, and it is an important sign (or early
diagnosis and prediction of clinical course and prognosis of hematologic malignancy. The numb chin syndrome is usually associated with a poor prognosis although various
therapeutic strategies led to resolution of this syndrome.
We report 2 cases of numb chin syndrome ; one in acute leukemia in early course of disease before diagnosis of leukemia and the other in leptomeningeal seeding of
malignant lymphoma. The therapeutic response and prognosis were poor, a patient of malignant lymphoma expired in two months and a patient of acute leukemia is alive at
present but the disease was relapsed in 5 months after complete remission.
Keywords Numb chin syndrome; Hematologic malignancy; Prognosis;
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Korean J Hematol 1997; 32(3): 446-452
Published online September 30, 1997
Copyright © The Korean Society of Hematology.
Numb chin 증후군을 동반한 악성 혈액 질환 2례
채경수, 지재환, 이정애, 안진석, 우인숙, 박영이, 박영석, 박지영, 조현찬
한림대학교 의과대학 내과학교실,
한림대학교 의과대학 임상병리학교실
Numb Chin Syndrome in Malignant Disease
Gyeong Soo Chae, Jae Hwan Jee, Jung Ae Lee, Jin Seok Ahn, In Sook Woo, Young lee Park, Young Suk Park, Ji Young Park, Hyun Chan Cho
Department of Internal Medicine,Clinical Pathology, Hallym University College of Medicine, Chuncheon, Korea
Abstract
The numb chin syndrome(NCS) is characterized by chin or lower lip numbness restricted to the distribution of mental nerve(the distal trigeminal nerve). This uncommon neuropathy may be associated with neoplastic disease and usually appeared as a late manifestation of systemic malignancy, and it is an important sign (or early
diagnosis and prediction of clinical course and prognosis of hematologic malignancy. The numb chin syndrome is usually associated with a poor prognosis although various
therapeutic strategies led to resolution of this syndrome.
We report 2 cases of numb chin syndrome ; one in acute leukemia in early course of disease before diagnosis of leukemia and the other in leptomeningeal seeding of
malignant lymphoma. The therapeutic response and prognosis were poor, a patient of malignant lymphoma expired in two months and a patient of acute leukemia is alive at
present but the disease was relapsed in 5 months after complete remission.
Keywords: Numb chin syndrome, Hematologic malignancy, Prognosis,
