Blood Res (2024) 59:5

Published online February 26, 2024

https://doi.org/10.1007/s44313-024-00009-7

© The Korean Society of Hematology

Peripheral T-cell lymphoma, NOS in bone marrow and heart

Hye Won Lee1 and Ja Young Lee1*

1Department of Laboratory Medicine, Busan Paik Hospital, Inje University College of Medicine, 75 Bokji‑Ro Busanjin‑Gu, Busan 47392, Korea

Correspondence to : *Ja Young Lee
liring@hanmail.net

Received: January 3, 2024; Accepted: February 13, 2024

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

A 65-year-old man was admitted presenting dyspnea aggravated by changes in posture. Three months earlier, he had been diagnosed with tuberculosis pericarditis and hypertension. Peripheral blood smear revealed the presence of atypical large lymphocytes characterized by azurophilic cytoplasmic granules (1%) and severe thrombocytopenia (platelet count of 40 × 109/L) (A, Wright-Giemsa stain, 1,000 ×). Bone marrow (BM) aspiration revealed an increased proportion of large lymphocytes, reaching up to 56.4% (B, Wright-Giemsa stain, 1,000 ×). Flow cytometry analysis identified an expanded CD4 + /CD8 + mature T-cell population with aberrant expression of CD19 and CD56, and a predominant CD8 expression (C, T-lymphoid cells appear red except in the last figure, in which CD8-dominant lymphoid cells appear blue). Chromosomal analysis of BM aspirate showed malignant clones exhibiting a complex karyotype. A subsequent pericardial biopsy confirmed the diagnosis of peripheral T-cell lymphoma with cardiac and BM involvement. Chemotherapy was initiated with cyclophosphamide, doxorubicin, vincristine, and prednisolone. Unfortunately, the patient died two weeks after diagnosis. Cardiac T-cell lymphoma with BM involvement is extremely rare. Due to the aggressive and rapidly expanding nature of primary cardiac lymphoma—a life-threatening malignancy—prompt and precise diagnosis and treatment are crucial.

Hye Won Lee and Ja Young Lee wrote the main manuscript test and Hye Won Lee prepared figures. All authors reviewed the manuscript.

No datasets were generated or analysed during the current study.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Ethics approval and consent to participate

Ethical approval was waived by the local Ethics Committee of Inje University Busan Paik Hospital in view of the retrospective nature of the study and the fact that all the procedures being performed were part of routine care (No. BPIRB 2023–09-045).

Competing interests

The authors declare no competing interests.

Article

IMAGE

Blood Res 2024; 59():

Published online February 26, 2024 https://doi.org/10.1007/s44313-024-00009-7

Copyright © The Korean Society of Hematology.

Peripheral T-cell lymphoma, NOS in bone marrow and heart

Hye Won Lee1 and Ja Young Lee1*

1Department of Laboratory Medicine, Busan Paik Hospital, Inje University College of Medicine, 75 Bokji‑Ro Busanjin‑Gu, Busan 47392, Korea

Correspondence to:*Ja Young Lee
liring@hanmail.net

Received: January 3, 2024; Accepted: February 13, 2024

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Body

A 65-year-old man was admitted presenting dyspnea aggravated by changes in posture. Three months earlier, he had been diagnosed with tuberculosis pericarditis and hypertension. Peripheral blood smear revealed the presence of atypical large lymphocytes characterized by azurophilic cytoplasmic granules (1%) and severe thrombocytopenia (platelet count of 40 × 109/L) (A, Wright-Giemsa stain, 1,000 ×). Bone marrow (BM) aspiration revealed an increased proportion of large lymphocytes, reaching up to 56.4% (B, Wright-Giemsa stain, 1,000 ×). Flow cytometry analysis identified an expanded CD4 + /CD8 + mature T-cell population with aberrant expression of CD19 and CD56, and a predominant CD8 expression (C, T-lymphoid cells appear red except in the last figure, in which CD8-dominant lymphoid cells appear blue). Chromosomal analysis of BM aspirate showed malignant clones exhibiting a complex karyotype. A subsequent pericardial biopsy confirmed the diagnosis of peripheral T-cell lymphoma with cardiac and BM involvement. Chemotherapy was initiated with cyclophosphamide, doxorubicin, vincristine, and prednisolone. Unfortunately, the patient died two weeks after diagnosis. Cardiac T-cell lymphoma with BM involvement is extremely rare. Due to the aggressive and rapidly expanding nature of primary cardiac lymphoma—a life-threatening malignancy—prompt and precise diagnosis and treatment are crucial.

Funding

No funding was received for conducting this study.

Authors’ contributions

Hye Won Lee and Ja Young Lee wrote the main manuscript test and Hye Won Lee prepared figures. All authors reviewed the manuscript.

Availability of data and materials

No datasets were generated or analysed during the current study.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Declarations

Ethics approval and consent to participate

Ethical approval was waived by the local Ethics Committee of Inje University Busan Paik Hospital in view of the retrospective nature of the study and the fact that all the procedures being performed were part of routine care (No. BPIRB 2023–09-045).

Competing interests

The authors declare no competing interests.

Blood Res
Volume 59 2024

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