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Case Report

Korean J Hematol 2009; 44(3):

Published online September 30, 2009

https://doi.org/10.5045/kjh.2009.44.3.182

© The Korean Society of Hematology

다발성 골수종과 Ankylosing Spondylitis 관계

문형일, 장형진, 김지은, 고훈영, 안소희, 민창기

가톨릭대학 의과대학 내과학교실

The Association between Multiple Myeloma and Ankylosing Spondylitis

Hyung Il Moon, Hyoung Jin Chang, Ji Eun Kim, Hoon Young Ko, Soe Hee Ann, Chang Ki Min

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Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

Abstract

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Multiple myeloma is a malignant disease of plasma cells, whereas ankylosing spondylitis is a chronic inflammatory disease of axial joints. The relationship between the two diseases is uncertain, but chronic inflammation could trigger multiple myeloma. The authors report the cases of two ankylosing spondylitis patients with a disease duration of more than 20 years, that subsequently developed IgA kappa and IgG lambda chain myeloma, respectively, and discuss the possible pathogenetic relationship between these diseases. (Korean J Hematol 2009;44:182-187.)

Keywords Multiple myeloma, Monoclonal gammopathy of undetermined significance, Ankylosing spondylitis, Inflammation, Tumor

Article

Case Report

Korean J Hematol 2009; 44(3): 182-187

Published online September 30, 2009 https://doi.org/10.5045/kjh.2009.44.3.182

Copyright © The Korean Society of Hematology.

다발성 골수종과 Ankylosing Spondylitis 관계

문형일, 장형진, 김지은, 고훈영, 안소희, 민창기

가톨릭대학 의과대학 내과학교실

The Association between Multiple Myeloma and Ankylosing Spondylitis

Hyung Il Moon, Hyoung Jin Chang, Ji Eun Kim, Hoon Young Ko, Soe Hee Ann, Chang Ki Min

Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

Abstract

Multiple myeloma is a malignant disease of plasma cells, whereas ankylosing spondylitis is a chronic inflammatory disease of axial joints. The relationship between the two diseases is uncertain, but chronic inflammation could trigger multiple myeloma. The authors report the cases of two ankylosing spondylitis patients with a disease duration of more than 20 years, that subsequently developed IgA kappa and IgG lambda chain myeloma, respectively, and discuss the possible pathogenetic relationship between these diseases. (Korean J Hematol 2009;44:182-187.)

Keywords: Multiple myeloma, Monoclonal gammopathy of undetermined significance, Ankylosing spondylitis, Inflammation, Tumor

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