Case Report

Korean J Hematol 2009; 44(1):

Published online March 30, 2009

https://doi.org/10.5045/kjh.2009.44.1.62

© The Korean Society of Hematology

신이식 환자에서 발생한 필라델피아 양성 급성 림프구성 백혈병 1예

백선경 조경삼 양병혁 김시영 윤휘중 정경환 임천규

서울대학병원 내과,
경희의료원 내과

Complete Hematologic Response and Cytogenetic Remission after Imatinib and Dexamethasone Treatment of a Ph+ Precursor B-cell Acute Lymphoblastic Leukemia in Renal Transplantation Patient

Sun Kyung Baek, Kyung Sam Cho, Byung Hyuk Yang, Si Young Kim, Hwi Joong Yoon, Kyung hwan Jeong, Chun Gyoo Ihm

Department of Internal Medicine, Seoul National University Hospital, Kyung Hee University Medical Center, Seoul, Korea

Abstract

In this report, we present a case of a patient with Philadelphia chromosome-positive (Ph+) B-cell acute lymphoblastic leukemia after renal transplantation. The patient, a 65-year-old man, had received a kidney transplantation 20 years prior to diagnosis with Ph+ precursor B-cell ALL. Because he was refractory to intensive chemotherapy and had refused to receive additional intensive chemotherapy, he was treated with imatinib and dexamethasone. While this patient experienced a complete hematologic and cytogenetic response, he did not show a complete molecular remission. Eighty days after imatinib combination therapy, the patient relapsed and died from intracerebral hemorrhage. (Korean J Hematol 2009;44:62-66.)

Keywords Renal transplantation, Philadelphia chromosome, Acute lymphoblastic leukemia, Imatinib

Article

Case Report

Korean J Hematol 2009; 44(1): 62-65

Published online March 30, 2009 https://doi.org/10.5045/kjh.2009.44.1.62

Copyright © The Korean Society of Hematology.

신이식 환자에서 발생한 필라델피아 양성 급성 림프구성 백혈병 1예

백선경 조경삼 양병혁 김시영 윤휘중 정경환 임천규

서울대학병원 내과,
경희의료원 내과

Complete Hematologic Response and Cytogenetic Remission after Imatinib and Dexamethasone Treatment of a Ph+ Precursor B-cell Acute Lymphoblastic Leukemia in Renal Transplantation Patient

Sun Kyung Baek, Kyung Sam Cho, Byung Hyuk Yang, Si Young Kim, Hwi Joong Yoon, Kyung hwan Jeong, Chun Gyoo Ihm

Department of Internal Medicine, Seoul National University Hospital, Kyung Hee University Medical Center, Seoul, Korea

Abstract

In this report, we present a case of a patient with Philadelphia chromosome-positive (Ph+) B-cell acute lymphoblastic leukemia after renal transplantation. The patient, a 65-year-old man, had received a kidney transplantation 20 years prior to diagnosis with Ph+ precursor B-cell ALL. Because he was refractory to intensive chemotherapy and had refused to receive additional intensive chemotherapy, he was treated with imatinib and dexamethasone. While this patient experienced a complete hematologic and cytogenetic response, he did not show a complete molecular remission. Eighty days after imatinib combination therapy, the patient relapsed and died from intracerebral hemorrhage. (Korean J Hematol 2009;44:62-66.)

Keywords: Renal transplantation, Philadelphia chromosome, Acute lymphoblastic leukemia, Imatinib

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