Original Article
Korean J Hematol 2007; 42(3):
Published online September 30, 2007
https://doi.org/10.5045/kjh.2007.42.3.250
© The Korean Society of Hematology
FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype
김형준, 김상호, 김여경, 이일권, 조덕연, 원종호, 곽재용, 임창열, 박무림, 양덕환, 조상희, 이제중, 정익주
전남대학 의과대학 내과
화순전남대병원 게놈연구센터
충남대학 의과대학 내과
순천향대학 의과대학 내과
전북대학 의과대학 내과
원광대 의과대학 혈액종양내과
FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype
Background:
The presence of FLT3 internal tandem dupulication (FLT3/ITD) in patients with acute myeloid leukemia (AML) with normal karyotype was investigated in order to evaluate its clinical and prognostic significance.
Methods:
The FLT3/ITD was studied by PCR assay in bone marrow samples obtained from 123 patients at diagnosis. Ninety patients who received intensive induction chemotherapy were evaluated.
Results:
Of total 123 patients, forty-seven (38.2%) demonstrated the aberrant FLT3/ITD. Patients with FLT3/ITD had significantly higher leukocyte counts at presentation than did patients without FLT3/ITD (P=0.04). By multivariate analysis, the FLT3/ITD was an independent prognostic factor of leukemic-free survival (LFS) (P=0.01) in AML patients with normal karyotype.
Conclusion:
This study demonstrated that the presence of the FLT3/ITD was a significant factor for poor prognosis in AML patients with normal karyotype.
Keywords FLT3/ITD, Acute myeloid leukemia, Normal karyotype
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Original Article
Korean J Hematol 2007; 42(3): 250-257
Published online September 30, 2007 https://doi.org/10.5045/kjh.2007.42.3.250
Copyright © The Korean Society of Hematology.
FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype
김형준, 김상호, 김여경, 이일권, 조덕연, 원종호, 곽재용, 임창열, 박무림, 양덕환, 조상희, 이제중, 정익주
전남대학 의과대학 내과
화순전남대병원 게놈연구센터
충남대학 의과대학 내과
순천향대학 의과대학 내과
전북대학 의과대학 내과
원광대 의과대학 혈액종양내과
FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype
Sang Ho Kim, Yeo Kyeoung Kim, Il, Kwon Lee, Deog Yeon Jo, Jong Ho Won, Jae Yong Kwak, Chang Yeol Yim, Moo Rim Park, Deok Hwan Yang, Sang Hee Cho, Je Jung Lee, Ik Joo Chung, Hyeoung Joon Kim
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, Chungnam National University College of Medicine, Cheongju, Soonchunhyang University College of Medicine, Seoul, Chonbuk National University Medical School, Jeonju, Department of Hematology, Oncology, Wonkwang University School of Medicin, Iksan, Korea
Abstract
Background:
The presence of FLT3 internal tandem dupulication (FLT3/ITD) in patients with acute myeloid leukemia (AML) with normal karyotype was investigated in order to evaluate its clinical and prognostic significance.
Methods:
The FLT3/ITD was studied by PCR assay in bone marrow samples obtained from 123 patients at diagnosis. Ninety patients who received intensive induction chemotherapy were evaluated.
Results:
Of total 123 patients, forty-seven (38.2%) demonstrated the aberrant FLT3/ITD. Patients with FLT3/ITD had significantly higher leukocyte counts at presentation than did patients without FLT3/ITD (P=0.04). By multivariate analysis, the FLT3/ITD was an independent prognostic factor of leukemic-free survival (LFS) (P=0.01) in AML patients with normal karyotype.
Conclusion:
This study demonstrated that the presence of the FLT3/ITD was a significant factor for poor prognosis in AML patients with normal karyotype.
Keywords: FLT3/ITD, Acute myeloid leukemia, Normal karyotype
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