Blood Res 2019; 54(4):
Published online December 31, 2019
https://doi.org/10.5045/br.2019.54.4.241
© The Korean Society of Hematology
Correspondence to : Nicolas Athanase, M.D., Laboratoire de Biologie M?dicale, Centre Hospitalier Agen-N?rac, Route de Villeneuve sur Lot, Saint-Esprit 47923 Agen, France, E-mail: athanase.nicolas@gmail.com, athanasen@ch-agen-nerac.fr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
An 82-year-old woman was admitted for cardiac insufficiency associated with obesity, renal insufficiency, and refractory atrial fibrillation. The patient had no history of hematological malignancies. Clinical examination revealed no lymphadenopathy, tumoral syndrome, or weight loss. Hematological tests showed the following: platelets, 173×109/L; hemoglobin, 10.3 g/dL; white blood cells, 10.5×109/L; and lymphocytes, 5.60×109/L. Cytological examination of blood smear indicated the presence of small lymphocytes with very mature chromatin, regular nuclei, and multiple intracytoplasmic sharp vacuoles, accounting for 41% of the total lymphocytes, as determined by manual differential white blood cell count (Panel
Vacuoles in lymphocytes have been reported in lysosomal storage diseases and neoplastic disorders; moreover, they are physiologically present in T and natural killer lymphocytes. Although vacuoles are more or less specific, they deserve attention as they can offer valuable insights.
Blood Res 2019; 54(4): 241-241
Published online December 31, 2019 https://doi.org/10.5045/br.2019.54.4.241
Copyright © The Korean Society of Hematology.
Nicolas Athanase
Laboratoire d’hématologie, Centre Hospitalier Agen-Nérac, Agen, France
Correspondence to:Nicolas Athanase, M.D., Laboratoire de Biologie M?dicale, Centre Hospitalier Agen-N?rac, Route de Villeneuve sur Lot, Saint-Esprit 47923 Agen, France, E-mail: athanase.nicolas@gmail.com, athanasen@ch-agen-nerac.fr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
An 82-year-old woman was admitted for cardiac insufficiency associated with obesity, renal insufficiency, and refractory atrial fibrillation. The patient had no history of hematological malignancies. Clinical examination revealed no lymphadenopathy, tumoral syndrome, or weight loss. Hematological tests showed the following: platelets, 173×109/L; hemoglobin, 10.3 g/dL; white blood cells, 10.5×109/L; and lymphocytes, 5.60×109/L. Cytological examination of blood smear indicated the presence of small lymphocytes with very mature chromatin, regular nuclei, and multiple intracytoplasmic sharp vacuoles, accounting for 41% of the total lymphocytes, as determined by manual differential white blood cell count (Panel
Vacuoles in lymphocytes have been reported in lysosomal storage diseases and neoplastic disorders; moreover, they are physiologically present in T and natural killer lymphocytes. Although vacuoles are more or less specific, they deserve attention as they can offer valuable insights.