Department of Pathology and Laboratory Medicine, Medanta-The Medicity, Gurgaon, India.
A 60-year-old man presented with fever for 2 weeks. Ultrasonography and contrast-enhanced abdominal computed tomography revealed retroperitoneal and mesenteric lymphadenopathy. Fine-needle aspiration cytology of a right inguinal lymph node showed a monotonous population of abnormal lymphoid cells, suggestive of non-Hodgkin's lymphoma. Bone marrow (BM) aspirate revealed sheets of abnormal lymphoid cells (90%) on a background of lymphoglandular bodies (
Lymphoglandular bodies are round, pale, basophilic fragments of cytoplasm in lymphoid tissues. They are most commonly seen in fine-needle aspiration cytology smears in cases of hematolymphoid neoplasms, and more often in B-cell neoplasms than T-cell lymphomas or myeloid leukemias. Whenever a BM aspirate shows lymphoglandular bodies, a high index of suspicion for hematolymphoid neoplasms, especially B-cell neoplasms, should be kept in mind. Furthermore, in high-grade lymphoma with blast-like morphology in the BM, presence of lymphoglandular bodies may favor a diagnosis of lymphoma rather than acute leukemia, which can be further confirmed and classified by immunohistochemistry.