Letter to the Editor

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Blood Res 2016; 51(3):

Published online September 23, 2016

https://doi.org/10.5045/br.2016.51.3.213

© The Korean Society of Hematology

Delta beta thalassemia: a rare hemoglobin variant

Huma Mansoori*, Sidra Asad, Anila Rashid, and Farheen Karim

Department of Haematology, Aga Khan University Hospital, Karachi, Pakistan.

Correspondence to : Huma Mansoori. Department of Haematology, Aga Khan University Hospital, Stadium Road P. O. Box 3500 Karachi 74800, Pakistan. huma.omair1986@gmail.com

Received: July 23, 2015; Revised: November 26, 2015; Accepted: January 10, 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fig. 1.

(A) Peripheral blood smear of the patient with anisopoikilocytosis and target cells. (B) Highperformance liquid chromatography showing 100% HbF indicated by the arrow. (C) Pan-cellular pattern on the Kleihauer-Bekte test.


Table. 1.

Table 1 Laboratory parameters of the case and parents.

Abbreviations: CBC, complete blood count; Hb, hemoglobin; HPLC, high-performance liquid chromatography.


  1. Bain BJ. Haemoglobinopathy diagnosis. Oxford, UK: Blackwell Publishing Ltd; 2006. p. 116-124.
  2. Bollekens, JA, Forget, BG. Delta beta thalassemia and hereditary persistence of fetal hemoglobin. Hematol Oncol Clin North Am, 1991;5;399-422.
    Pubmed
  3. Khunger, JM, Gupta, M, Singh, R, Kapoor, R, Pandey, HR. Haematological characterisation and molecular basis of asian Indian inversion deletions delta Beta thalassemia: a case report. J Clin Diagn Res, 2014;8;FD01-FD02.
  4. Verma, S, Bhargava, M, Mittal, S, Gupta, R. Homozygous delta-beta thalassemia in a child: a rare cause of elevated fetal hemoglobin. Iran J Ped Hematol Oncol, 2013;3;222-227.
    Pubmed
  5. Ramot, B, Ben-Bassat, I, Gafni, D, Zaanoon, R. A family with three beta-delta-thalassemia homozygotes. Blood, 1970;35;158-165.
    Pubmed
  6. Silvestroni, E, Bianco, I, Reitano, G. Three cases of homozygous beta, delta-thalassemia (or microcythaemia) with high haemoglobin F in a Sicilian family. Acta Haematol, 1968;40;220-229.
    Pubmed

Article

Letter to the Editor

Blood Res 2016; 51(3): 213-214

Published online September 23, 2016 https://doi.org/10.5045/br.2016.51.3.213

Copyright © The Korean Society of Hematology.

Delta beta thalassemia: a rare hemoglobin variant

Huma Mansoori*, Sidra Asad, Anila Rashid, and Farheen Karim

Department of Haematology, Aga Khan University Hospital, Karachi, Pakistan.

Correspondence to: Huma Mansoori. Department of Haematology, Aga Khan University Hospital, Stadium Road P. O. Box 3500 Karachi 74800, Pakistan. huma.omair1986@gmail.com

Received: July 23, 2015; Revised: November 26, 2015; Accepted: January 10, 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Figure 1.

    (A) Peripheral blood smear of the patient with anisopoikilocytosis and target cells. (B) Highperformance liquid chromatography showing 100% HbF indicated by the arrow. (C) Pan-cellular pattern on the Kleihauer-Bekte test.

    Blood Research 2016; 51: 213-214https://doi.org/10.5045/br.2016.51.3.213

    Table 1 . Laboratory parameters of the case and parents..

    Abbreviations: CBC, complete blood count; Hb, hemoglobin; HPLC, high-performance liquid chromatography..


    References

    1. Bain BJ. Haemoglobinopathy diagnosis. Oxford, UK: Blackwell Publishing Ltd; 2006. p. 116-124.
    2. Bollekens, JA, Forget, BG. Delta beta thalassemia and hereditary persistence of fetal hemoglobin. Hematol Oncol Clin North Am, 1991;5;399-422.
      Pubmed
    3. Khunger, JM, Gupta, M, Singh, R, Kapoor, R, Pandey, HR. Haematological characterisation and molecular basis of asian Indian inversion deletions delta Beta thalassemia: a case report. J Clin Diagn Res, 2014;8;FD01-FD02.
    4. Verma, S, Bhargava, M, Mittal, S, Gupta, R. Homozygous delta-beta thalassemia in a child: a rare cause of elevated fetal hemoglobin. Iran J Ped Hematol Oncol, 2013;3;222-227.
      Pubmed
    5. Ramot, B, Ben-Bassat, I, Gafni, D, Zaanoon, R. A family with three beta-delta-thalassemia homozygotes. Blood, 1970;35;158-165.
      Pubmed
    6. Silvestroni, E, Bianco, I, Reitano, G. Three cases of homozygous beta, delta-thalassemia (or microcythaemia) with high haemoglobin F in a Sicilian family. Acta Haematol, 1968;40;220-229.
      Pubmed
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