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Letter to the Editor

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Blood Res 2016; 51(3):

Published online September 23, 2016

https://doi.org/10.5045/br.2016.51.3.206

© The Korean Society of Hematology

A case of histoplasmosis in a patient with MDS/MPN-U

Pulkit Rastogi1, Prashant Sharma1, Narender Kumar1*, Shivaprakash M. Rudramurthy1, Neelam Varma2, and Subhash Varma2

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1Department of Hematology and Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

2Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Correspondence to : Narender Kumar. Department of Hematology, Level 5, Research Block A, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. nkkalson@yahoo.co.in

Received: July 16, 2015; Revised: October 15, 2015; Accepted: November 12, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

FIGURES

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Fig. 1.

(A) Peripheral blood shows neutrophils with toxic granules and two intra-cytoplasmic yeast forms of Histoplasma capsulatum in the cell on the left (May-Grunwald Giemsa, ×1,000). Inset: The fungus was brightly positive for periodic acid–Schiff stain (hematoxylin counterstain, ×1,000). (B) Hemodilute bone marrow smears showed dysgranulopoiesis with 5% blasts (May-Grunwald Giemsa, ×1,000). Inset: Ring sideroblasts comprised 32% of all cells (Perls' Prussian Blue reaction with neutral red counterstain, ×1,000). (C) Bone marrow biopsy showed intracellular yeast forms (hematoxylin and eosin, ×400). Inset: These were positive for Grocott's silver methenamine stain (methyl green counterstain, ×1,000). (D) Lactophenol cotton blue wet-mount preparation of the isolated mold shows thick-walled and tuberculate macroconidia, with a close-up in the inset (lactophenol cotton blue stain, ×1,000).


REFERENCES

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  1. Vardiman JW, Bennett JM, Bain BJ, Baumann I, Thiele J, Orazi A. In: Swerdlow SH, Campo E, Harris NL. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press; 2008. p. 85-86.
  2. Sharma, P, Tyagi, S. An unusual cause of eosinophilia in aml-m4 without the Inv(16) abnormality. J Blood Disord Transfus, 2010;1;104.
  3. Mazzone, A, Porta, C, Fossati, G, Gritti, D, Mazzucchelli, I, Ricevuti, G. Granulocyte dysplasia and dysfunction, and CD11/CD18 defects in myelodysplastic syndromes. Leuk Lymphoma, 1996;23;267-275.
    Pubmed

Article

Letter to the Editor

Blood Res 2016; 51(3): 206-207

Published online September 23, 2016 https://doi.org/10.5045/br.2016.51.3.206

Copyright © The Korean Society of Hematology.

A case of histoplasmosis in a patient with MDS/MPN-U

Pulkit Rastogi1, Prashant Sharma1, Narender Kumar1*, Shivaprakash M. Rudramurthy1, Neelam Varma2, and Subhash Varma2

1Department of Hematology and Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

2Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Correspondence to: Narender Kumar. Department of Hematology, Level 5, Research Block A, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. nkkalson@yahoo.co.in

Received: July 16, 2015; Revised: October 15, 2015; Accepted: November 12, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

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    Figure 1.

    (A) Peripheral blood shows neutrophils with toxic granules and two intra-cytoplasmic yeast forms of Histoplasma capsulatum in the cell on the left (May-Grunwald Giemsa, ×1,000). Inset: The fungus was brightly positive for periodic acid–Schiff stain (hematoxylin counterstain, ×1,000). (B) Hemodilute bone marrow smears showed dysgranulopoiesis with 5% blasts (May-Grunwald Giemsa, ×1,000). Inset: Ring sideroblasts comprised 32% of all cells (Perls' Prussian Blue reaction with neutral red counterstain, ×1,000). (C) Bone marrow biopsy showed intracellular yeast forms (hematoxylin and eosin, ×400). Inset: These were positive for Grocott's silver methenamine stain (methyl green counterstain, ×1,000). (D) Lactophenol cotton blue wet-mount preparation of the isolated mold shows thick-walled and tuberculate macroconidia, with a close-up in the inset (lactophenol cotton blue stain, ×1,000).

    Blood Research 2016; 51: 206-207https://doi.org/10.5045/br.2016.51.3.206

    References

    1. Vardiman JW, Bennett JM, Bain BJ, Baumann I, Thiele J, Orazi A. In: Swerdlow SH, Campo E, Harris NL. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press; 2008. p. 85-86.
    2. Sharma, P, Tyagi, S. An unusual cause of eosinophilia in aml-m4 without the Inv(16) abnormality. J Blood Disord Transfus, 2010;1;104.
    3. Mazzone, A, Porta, C, Fossati, G, Gritti, D, Mazzucchelli, I, Ricevuti, G. Granulocyte dysplasia and dysfunction, and CD11/CD18 defects in myelodysplastic syndromes. Leuk Lymphoma, 1996;23;267-275.
      Pubmed
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