Regenerating blasts masquerading as relapse in a patient with ALL following G-CSF therapy

Ritesh Sachdev; Tushar Sahni; Smeeta Gajendra; Bhawna Jha; Shalini Goel; Pranav Dorwal

doi:10.5045/br.2015.50.1.54

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Letter to the Editor

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Blood Res 2015; 50(1):

Published online March 31, 2015

https://doi.org/10.5045/br.2015.50.1.54

Regenerating blasts masquerading as relapse in a patient with ALL following G-CSF therapy

Ritesh Sachdev^*, Tushar Sahni, Smeeta Gajendra, Bhawna Jha, Shalini Goel, and Pranav Dorwal

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Department of Pathology and Laboratory Medicine, Medanta-The Medicity, Gurgaon, India.

Correspondence to : Ritesh Sachdev. Department of Pathology and Laboratory Medicine, Medanta-The Medicity, Sector-38, Gurgaon, Haryana 122 001, India. sachdev05@gmail.com

Received: July 18, 2014; Revised: August 5, 2014; Accepted: February 12, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1.

(A) Diagnostic blasts with a high nucleocytoplasmic ratio and scant agranular cytoplasm (Giemsa stain, ×1,000). (B) Regenerating blasts are larger with moderate granular cytoplasm (Giemsa stain, ×1,000). (C-F) Immunophenotyping showing the regenerating blasts positive for CD45, CD34, CD13, and CD33 and negative for CD19 and CD10.

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REFERENCES

Liu, CZ, Persad, R, Inghirami, G, et al. Transient atypical monocytosis mimic acute myelomonocytic leukemia in post-chemotherapy patients receiving G-CSF: report of two cases. Clin Lab Haematol, 2004;26;359-362.
Arici, M, Hazendaroğlu, IC, Erman, M, Ozcebe, O. Leukoerythroblastosis following the use of G-CSF. Am J Hematol, 1996;52;123-124.
Imataki, O, Ohnishi, H, Yamaoka, G, et al. Marked increase of normal blast morphologically mimicking leukemic clone in acute lymphoblastic leukemia patient following G-CSF therapy. Int J Hematol, 2008;88;468-470.
Hosokawa, T, Tomoda, T, Misaki, Y, Wakiguchi, H, Kurashige, T. Marked increase of peripheral blood myeloblasts following G-CSF therapy in a patient with acute lymphoblastic leukemia. Acta Paediatr Jpn, 1995;37;78-80.

Article

Letter to the Editor

Blood Res 2015; 50(1): 54-55

Published online March 31, 2015 https://doi.org/10.5045/br.2015.50.1.54

Regenerating blasts masquerading as relapse in a patient with ALL following G-CSF therapy

Ritesh Sachdev^*, Tushar Sahni, Smeeta Gajendra, Bhawna Jha, Shalini Goel, and Pranav Dorwal

Department of Pathology and Laboratory Medicine, Medanta-The Medicity, Gurgaon, India.

Correspondence to: Ritesh Sachdev. Department of Pathology and Laboratory Medicine, Medanta-The Medicity, Sector-38, Gurgaon, Haryana 122 001, India. sachdev05@gmail.com

Received: July 18, 2014; Revised: August 5, 2014; Accepted: February 12, 2015

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Blood Research 2015; 50: 54-55https://doi.org/10.5045/br.2015.50.1.54

References

Liu, CZ, Persad, R, Inghirami, G, et al. Transient atypical monocytosis mimic acute myelomonocytic leukemia in post-chemotherapy patients receiving G-CSF: report of two cases. Clin Lab Haematol, 2004;26;359-362.
Arici, M, Hazendaroğlu, IC, Erman, M, Ozcebe, O. Leukoerythroblastosis following the use of G-CSF. Am J Hematol, 1996;52;123-124.
Imataki, O, Ohnishi, H, Yamaoka, G, et al. Marked increase of normal blast morphologically mimicking leukemic clone in acute lymphoblastic leukemia patient following G-CSF therapy. Int J Hematol, 2008;88;468-470.
Hosokawa, T, Tomoda, T, Misaki, Y, Wakiguchi, H, Kurashige, T. Marked increase of peripheral blood myeloblasts following G-CSF therapy in a patient with acute lymphoblastic leukemia. Acta Paediatr Jpn, 1995;37;78-80.