Transplant characteristics and outcomes.
Patient no. | Time from diagnosis to HSCT, mo | Type of donor | Conditioning regimen | Acute GVHD | Chronic GVHD | a)Performance score before HSCT, % | a)Performance score after HSCT, % | Disease status | Survival |
---|---|---|---|---|---|---|---|---|---|
1 | 12.2 | URD | FluBuCy | No | No | 50 | 90 | CR | Alive |
2 | 28.7 | MSD | FluBuCy | No | Yes, limited | 70 | 100 | CR | Alive |
3 | 4.8 | MSD | FluBuCy | No | No | 90 | 100 | CR | Alive |
4 | 7.4 | MSD (syngeneic) | FluBuCyATG | No | No | 70 | - | NR | Dead (DOD) |
5 | 5.4 | URD | FluBuCyATG | Yes (Gr 2, skin) | No | 90 | 100 | CR | Alive |
6 | 6.1 | URD | FluBuCyATG | No | No | 90 | 100 | CR | Alive |
7 | 3.1 | MSD | FluBuCy b)VpATG | No | Yes, extensive | 70 | - | CR | Dead (TRM) |
8 | 5.0 | MSD | FluBuCy b)VpATG | No | No | 90 | 100 | CR | Alive |
9 | 28.2 | URD | FluBuCyATG | Yes (Gr 2, skin and gut) | No | 70 | 80 | CR | Alive |
a)Performance score was evaluated using the Lansky score, which was not provided to patients who died. b)Patients who developed HLH flare during conditioning received additional doses of VP-16 and dexamethasone.
Abbreviations: CR, complete response; DOD, death from disease; GVHD, graft-versus-host disease; HSCT, hematopoietic stem cell transplantation; MSD, matched sibling donor; NA, not available; NR, nonresponse; PR, partial response; TRM, treatment-related mortality; URD, unrelated donor.