Blood Research

Transplant characteristics and outcomes.

Patient no. Time from diagnosis to HSCT, mo Type of donor Conditioning regimen Acute GVHD Chronic GVHD a)Performance score before HSCT, % a)Performance score after HSCT, % Disease status Survival
1 12.2 URD FluBuCy No No 50 90 CR Alive
2 28.7 MSD FluBuCy No Yes, limited 70 100 CR Alive
3 4.8 MSD FluBuCy No No 90 100 CR Alive
4 7.4 MSD (syngeneic) FluBuCyATG No No 70 - NR Dead (DOD)
5 5.4 URD FluBuCyATG Yes (Gr 2, skin) No 90 100 CR Alive
6 6.1 URD FluBuCyATG No No 90 100 CR Alive
7 3.1 MSD FluBuCy b)VpATG No Yes, extensive 70 - CR Dead (TRM)
8 5.0 MSD FluBuCy b)VpATG No No 90 100 CR Alive
9 28.2 URD FluBuCyATG Yes (Gr 2, skin and gut) No 70 80 CR Alive

a)Performance score was evaluated using the Lansky score, which was not provided to patients who died. b)Patients who developed HLH flare during conditioning received additional doses of VP-16 and dexamethasone.

Abbreviations: CR, complete response; DOD, death from disease; GVHD, graft-versus-host disease; HSCT, hematopoietic stem cell transplantation; MSD, matched sibling donor; NA, not available; NR, nonresponse; PR, partial response; TRM, treatment-related mortality; URD, unrelated donor.

Blood Res 2022;57:152~157 https://doi.org/10.5045/br.2022.2022047
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