Table 1

Basic clinical characteristics of six patients with small-cell-type plasma cell leukemia.

	Present patient	Heerema-McKenney et al. [7]	Heerema-McKenney et al. [7]	Gounari et al. [8]	Loureiro et al. [9]	Teriaky et al. [10]
Sex/age (yr)	M/65	F/59	M/74	M/61	F/77	F/85
Initial CBC	WBC: 2.8×10⁹/L Hb: 47 g/L Platelet: 45×10⁹/L	NR	NR	WBC: 12.3×10⁹/L Hb: 98 g/L Platelet: 89×10⁹/L	WBC: 8.6×10⁹/L Hb: 101 g/L Platelet: 140×10⁹/L	WBC: 28.2×10⁹/L Hb: 92 g/L Platelet: 238×10⁹/L
Plasma cells (BM/PB), %	>80.0	>80.0	>80.0	54.0	90.0	75.0
Plasma cells (BM/PB), %	20.0	40.0	52.0	22.7	43.5	74.0
Immunophenotyping results	CD45^-/CD19^-/CD20⁺/CD38⁺/CD138⁺/CD56^-/CD117⁺/cCD79a⁺/ FMC7⁺ and lambda restriction	CD45^-/CD20^-/CD38⁺/CD138⁺/CD56^-/CD117^-	CD45^-/CD38⁺/CD138⁺	CD45^-/CD19^-/CD20^dim+/CD38⁺/CD138⁺/CD56^-/CD200⁺ and kappa restriction	CD45^-/CD19^-/ CD38⁺/CD138^dim+/CD56^-/CD117^-/CD28^-/CD81⁺ and kappa restriction	CD45^-/CD19^partia+l/CD20^dim+/CD38⁺/CD138⁺ and kappa restriction
PEP/IFE	IgA-lambda (5 g/L^a))	IgG-lambda (4g/L^a))	IgG-lambda (30g/L^a))	IgA-kappa	IgG-kappa (44g/L^a))	kappa
Cytogenetic study	42,XY,-1,-9,-10, ?t(11;14)(q13;q32),-14,-16,?add(17)(p11.2)der(19) t(1;19)(p13;p13.3),-20,-21, +der(?)t(?;21)(?;q11.2), +2mar[6]/46,XY [14]	46,XX[19]/45,XX,−20[11]	46,XY, t(11;14)(q12∼13.1;q32), del(13)(q14q22),?del(17)(p12)[cp2]/46,XY[18]	Hyperdiploid clone with trisomy 2, 3, 12, and 18	NR	NR
Molecular study	IGH/CCND1 rearrangement, 13q14 deletion, p53 (17p) deletion^b), TP53 (c.490A>G, p.Lys164Glu)^c)	Overexpression of MS4A1/CD20 and CCND2^d)	Overexpression of CCND1^d)	Overexpression CCND1^e)	IGH/CCND1 rearrangement^b)	NR
Disease course	Died after 5 months after allo-PBSCT	NR	NR	CR after CTx	Died 3 months after diagnosis	CR after CTx

^a)Amount of M protein. Results of the ^b)FISH, ^c)NGS study, ^d)gene expression profiling (GEP) analysis, and ^e)immunohistochemical staining.

Abbreviations: allo-PBSCT, allogeneic peripheral blood stem cell transplantation; CBC, complete blood count; CR, complete remission; CTx, chemotherapy; IFE, immunofixation electrophoresis; NR, not reported; PEP, protein electrophoresis.

Blood Res 2022;57:161~164 https://doi.org/10.5045/br.2022.2022059