Immunoglobulin data.
| Ref range (mg/dL) |
All (N=23) | Control (N=6) | IVIG (N=17) | ||
|---|---|---|---|---|---|
| Baseline values (mg/dL) | |||||
| Baseline IgA, mg/dL, median (range) | 70–400 | 128 (40–544) | 117.5 (54–149) | 132 (40–544) | 0.18 |
| Baseline IgA hypogammaglobulinemia | 2 (9.5) | 1 (16.7) | 1 (6.7) | 0.5 | |
| Baseline IgM, mg/dL, median (range) | 40–230 | 41 (8–144) | 44 (8–117) | 41 (12–144) | 0.73 |
| Baseline IgM hypogammaglobulinemia | 9 (42.9) | 2 (33.3) | 7 (46.7) | 0.66 | |
| Baseline IgG, mg/dL, median (range) | 700–1,600 | 716 (321–1,783) | 836.5 (404–1,262) | 716 (321–1,783) | 0.97 |
| Baseline IgG hypogammaglobulinemia | 10 (47.6) | 3 (50) | 7 (46.7) | 1 | |
| Nadir values (mg/dL), median (range) | |||||
| IgA Nadira) | 70–400 | 18 (<5–42) | 11 (9–33) | 19 (<5–42) | 0.4 |
| Time to nadir | - | 101 (35–688) | 82 (48–109) | 119 (35–688) | 0.14 |
| IgM Nadira) | 40–230 | 9.5 (<5–47) | 10 (<5–47) | 9 (<5–38) | 0.93 |
| Time to nadir | - | 86 (35–688) | 82 (48–109) | 93 (35–688) | 0.45 |
| IgG, Nadir | 700–1,600 | 338 (221–1,006) | 337 (221–587) | 338 (258–1,006) | 0.64 |
| Time to nadir | - | 103 (28–435) | 85.5 (48–109) | 120.5 (28–435) | 0.13 |
| IgG <500 mg/dL, N (%) | - | 19 (86.4) | 5 (83.3) | 14 (87.5) | 1 |
| Last available immunoglobulin follow-up data, median (range) | |||||
| IgAa) | 70–400 | 31 (<5–325) | 20 (10–325) | 36 (<5–313) | 0.5 |
| Day from blinatumomab initiation, days | - | 244.5 (35–912) | 109 (48–382) | 285 (35–912) | 0.31 |
| IgMa) | 40–230 | 27.5 (<5–211) | 12 (<5–90) | 30 (<5–211) | 0.53 |
| Day from blinatumomab initiation, days | - | 244.5 (35–912) | 109 (48–382) | 279 (35–912) | 0.35 |
| IgG | 700–1,600 | 591.5 (221–2,346) | 787 (221–1,679) | 547 (268–2,346) | 0.91 |
| Day from blinatumomab initiation, days | - | 243 (35–912) | 141.5 (48–445) | 276.5 (35–912) | 0.49 |
| ANC <500 cells/µL at any time point, N (%) | - | 19 (82.6) | 6 (100) | 13 (76.5) | 0.54 |
| Time to ANC <500 cells/µL, days, median (range) | - | 71 (2–249) | 65.5 (2–109) | 96 (14–249) | 0.35 |
All values listed as N (%) unless otherwise noted.
a)A value of <5 indicates a result below the detectable level.
Abbreviations: ANC, absolute neutrophil count; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M.
Blood Res 2022;57:135~143 https://doi.org/10.5045/br.2022.2021163
© Blood Research
© 2024. BLOOD RESEARCH All rights reserved. Powered by INFOrang Co., Ltd