Fig. 3. Functional characterization of CD8⁺ cells. The percentage of (A) naïve/central memory (CM)/ effector memory (EM) T-cells by each histology and (B) by ex-pression of PD-1 and TIM-3 ex-pression. (C) Percent of total CD8⁺ T-cells that produce IFNγ . (D) IFNγ production by histology and memory subset. (E, F) Linear regression of CD8⁺ cells producing IFNγ and IL-2 versus the percentage of cells expressing PD-1. (G) IFNγ and (H) IL-2 production by CD8⁺ T-cells by expression of PD-1, TIM-3, and CTLA-4. Histologies were RH (N=2), FL (N=5), DLBCL (N=6). P-values as indicated.

© Blood Research