Table 1

Indications for treatment in low grade lymphoma.

Indication	Detail
High tumor burden [10]	Any site >7 cm
	Three or more sites >3 cm
	Splenomegaly (>16 cm)
	Pleural or peritoneal effusion
	Circulating tumor cells >5,000/mL
	Cytopenia secondary to lymphoma
	- Absolute neutrophil count <1,000/mL
	- Platelet count <100,000/mL
Disease-related symptoms	Fever
	Night sweats
	Weight loss
	Compression
	Other lymphoma-related symptoms
Steady progression	Over at least 6 months