Blood Research

Laboratory abnormalities by cause of thrombocytopenia.

GT ITP HT TTP aHUS PEC HELLP AFLP APS
CBC
PLT (×109/L) ≥75 Any, variable 20–130 <100 20–150 >50 (<50 in <5%) 50–100 >50 ≥50
Hemoglobin - - - ↓↓ ↓↓ -/↓ -/↓ - -
PBS - ±Few large PLTs ±Giant PLT or small PLTs ±WBC inclusions Schistocytes +++ Schistocytes +++ ±Schistocytes ±Schistocytes - ±Schistocytes
LDH - - - ↑↑↑↑ ↑↑↑ ↑↑ ↑↑↑ -
Creatinine - - - -/↑ ↑↑↑ -/↑ -/↑ -/↑
AST/ALT - - - -/↑ -/↑ - ↑↑↑ ↑↑↑ -/↑
Bilirubin
Direct - - - ↑↑ ↑↑ -/↑ ↑↑ ↑↑ -
Indirect - - - ↑↑ -
PT/aPTT - - - - - -/↑ ↑↑ -/↑
Urine protein - - - - -/↑
Other features - - - ADAMTS13 ≤10% ADAMTS13 >10% - - Hypoglycemia Antibody to cardiolipin and/or β2 glycoprotein and/or lupus anticoagulant

Adapted from Cines and Levine [1] Thrombocytopenia in pregnancy. Blood 2017;130:2271-7.

Abbreviations: AFLP, acute fatty liver of pregnancy; aHUS, atypical hemolytic uremic syndrome; ALT, alanine aminotransferase; APS, antiphospholipid syndrome; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; CBC, complete blood count; GT, gestational thrombocytopenia; HELLP, hemolysis, elevated liver enzyme and low platelet count; HT, hereditary thrombocytopenia; ITP, immune thrombocytopenia; LDH, lactate dehydrogenase; PBS, peripheral blood smear; PEC, preeclampsia; PLT, platelet; PT, prothrombin time; TTP, thrombotic thrombocytopenic purpura; WBC, white blood cell.

Blood Res 2022;57:S79~S85 https://doi.org/10.5045/br.2022.2022068
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