Laboratory abnormalities by cause of thrombocytopenia.
GT | ITP | HT | TTP | aHUS | PEC | HELLP | AFLP | APS | |
---|---|---|---|---|---|---|---|---|---|
CBC | |||||||||
PLT (×109/L) | ≥75 | Any, variable | 20–130 | <100 | 20–150 | >50 (<50 in <5%) | 50–100 | >50 | ≥50 |
Hemoglobin | - | - | - | ↓↓ | ↓↓ | -/↓ | -/↓ | - | - |
PBS | - | ±Few large PLTs | ±Giant PLT or small PLTs ±WBC inclusions | Schistocytes +++ | Schistocytes +++ | ±Schistocytes | ±Schistocytes | - | ±Schistocytes |
LDH | - | - | - | ↑↑↑↑ | ↑↑↑ | ↑ | ↑↑ | ↑↑↑ | - |
Creatinine | - | - | - | -/↑ | ↑↑↑ | -/↑ | ↑ | -/↑ | -/↑ |
AST/ALT | - | - | - | -/↑ | -/↑ | - | ↑↑↑ | ↑↑↑ | -/↑ |
Bilirubin | |||||||||
Direct | - | - | - | ↑↑ | ↑↑ | -/↑ | ↑↑ | ↑↑ | - |
Indirect | - | - | - | ↑↑ | ↑ | - | |||
PT/aPTT | - | - | - | - | - | -/↑ | ↑ | ↑↑ | -/↑ |
Urine protein | - | - | - | - | ↑ | ↑ | ↑ | -/↑ | ↑ |
Other features | - | - | - | ADAMTS13 ≤10% | ADAMTS13 >10% | - | - | Hypoglycemia | Antibody to cardiolipin and/or β2 glycoprotein and/or lupus anticoagulant |
Adapted from Cines and Levine [1] Thrombocytopenia in pregnancy. Blood 2017;130:2271-7.
Abbreviations: AFLP, acute fatty liver of pregnancy; aHUS, atypical hemolytic uremic syndrome; ALT, alanine aminotransferase; APS, antiphospholipid syndrome; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; CBC, complete blood count; GT, gestational thrombocytopenia; HELLP, hemolysis, elevated liver enzyme and low platelet count; HT, hereditary thrombocytopenia; ITP, immune thrombocytopenia; LDH, lactate dehydrogenase; PBS, peripheral blood smear; PEC, preeclampsia; PLT, platelet; PT, prothrombin time; TTP, thrombotic thrombocytopenic purpura; WBC, white blood cell.