Table 3

Metabolic response criteria using Deauville score (adapted from Lugano classification).

Response categories	FDG-PET/CT-based response
Complete metabolic response	Scores 1, 2 and 3 in nodal or extranodal sites with or without a residual mass using the five-point scale
Partial metabolic response	Score 4 or 5, with visually reduced uptake compared with baseline and residual mass(es) of any size
	- At interim these findings may suggest responding disease; at end of treatment these findings indicate residual metabolic disease
	- Bone marrow: residual marrow uptake>normal marrow but reduced compared with baseline (diffuse changes from chemotherapy allowed)
No metabolic response	Score 4 or 5 with no significant change in uptake from baseline (at interim or end of treatment)
Progressive metabolic disease	Score 4 or 5 with an increase in uptake from baseline and/or new FDG-avid foci consistent with lymphoma (at interim or end of treatment)