Summary of prospective and retrospective studies of treatment with novel agents for primary plasma cells leukemia.
References | Study design | Patients, N | Median age, yr (range) | ORR/CR (%) | ASCT, N |
Median PFS (mo) | Median OS (mo) |
---|---|---|---|---|---|---|---|
Musto |
Prospective | 23 | 60 (44–80) | 73.9/13 | 9 | 14 | 28 |
Royer |
Prospective | 39 | 57 (27–71) | 69/10 | 25 | 15.1 | 36.3 |
Nandakumar |
Retrospective | 68 | 62 (34–91) | 90/47 | 20 | 13 | 23 |
Dhakal |
Retrospective | 277 | 60 (25–77) | 87/19 | 277 | 17% at 4 yr | 28% at 4 yr |
Mina |
Retrospective | 38 | 58 (34–80) | 82/18 | 28 | 20 | 33 |
Gowda |
Retrospective | 23 | 56 (42–71) | 65/13 | 23 | 5.5 | 18.1 |
D’Arena |
Retrospective | 29 | 62 (42–82) | 79/28 | 12 | 40% at 2 yr | 55% at 2 yr |