Fig. 5. Representative immunohistochemical staining images of Hodgkin lymphomas. In classic Hodgkin lymphoma, tumor cells are positive for CD30 and CD15. CD20 is negative and PAX5 is weak positive in large tumor cells. In nodular lymphocyte predominant Hodgkin lymphoma, tumor cells are positive for CD20 and Oct-2. CD30 is negative in tumor cells. CD3 stain shows peritumoral rosette-like T-cells. Abbreviation: NLPHL, nodular lymphocyte predominant Hodgkin lymphoma.