Table 2

Response criteria.

Hematologic response	CR:negative bone marrow and negative immunofixation of serum and urine
	VGPR:over 90% reduction in M-protein, plus urine M-protein level of <100 mg per 24-h
	PR:50% reduction in M-protein or positive immunofixation as long as the baseline M protein is at least 1.0 g/dL
PET responses	CR:the disappearance of all FDG uptake lesions
	PR:≥50% improvement in the sum of the maximum standardized uptake value of FDG-avid lesions
	No response:the failure to meet CR or PR criteria
VEGF response (evaluable: ×2 UNL)	CR:normalization of VEGF
	PR:a decrease of over 50% VEGF
	No response:the failure to meet CR or PR criteria
	Progression:50% increase from the lowest level
Clinical response (clinical improvement, clinical progression, mixed clinical response, and clinical stability)	Peripheral neuropathy, organomegaly, papilledema, erythrocytosis/thrombocytosis, endocrinopathy, extravascular fluid overload (ascites, effusions, edema)
	Pulmonary function tests

Abbreviations: CR, complete response; PR, partial response; UNL, upper normal limit; VGPR,very good partial response.