Table 1

Cancer and Leukemia Group B1002 (CALGB 1002) protocol.

Cycle 1
Drug	Dose		Days
Cyclophosphamide		200 mg/m²		1–5
Prednisolone		60 mg/m²		1–7
Cycles 2, 4, and 6
Drug		Dose		Days
Ifosfamide		800 mg/m²		1–5
Mesna		200 mg/m²		1 to 5 (At h 0, 4, and 8 after ifosfamide)
Methotrexate		1,500 mg/m²		1
Leucovorin		25 mg/m² 36 h after starting methotrexate infusion, then 10 mg/m² until methotrexate level <0.05 μmol/L
Vincristine		2 mg		1
Cytarabine		1,000 mg/m²		4–5
Etoposide		80 mg/m²		4–5
Intrathecal
Methotrexate		15 mg		1
Cytarabine		40 mg
Hydrocortisone		50 mg
Rituximab		Cycle 2:
		50 mg/m², then		8
		375 mg/m²		10
		Cycles 4 and 6:
		375 mg/m²		8
Filgrastim		5 mcg/kg		Starting on day 7
Cycles 3, 5 and 7
Drug		Dose		Days
Cyclophosphamide		200 mg/m²		1–5
Methotrexate		1,500 mg/m²		1
Leucovorin		25 mg/m² 36 h after starting methotrexate infusion, then 10 mg/m² until methotrexate level <0.05 μmol/L
Vincristine		2 mg		1
Doxorubicin		25 mg/m²		4–5
Dexamethasone		10 mg/m²		4–5
Intrathecal
Methotrexate		15 mg		1
Cytarabine		40 mg
Hydrocortisone		50 mg
Rituximab		375 mg/m²		8
Filgrastim		5 mcg/kg		Starting on day 7