Table 6

Hazard ratios for the main outcomes during follow-up.

Covariate	Unadjusted model			Adjusted model
Covariate	HR	95% CI	P	aHR	95% CI	P
Thrombosis
Etiology^a)
OSA	0.32	0.13–0.77	0.012	0.16	0.05–0.51	0.002
CLD	1.20	0.47–3.07	0.71	0.99	0.38–2.62	0.99
Age (1=1 yr)	1.02	0.99–1.04	0.16	1.01	0.97–1.04	0.75
Male	1.03	0.46–2.30	0.94	1.40	0.57–3.42	0.46
BMI (1=1 kg/m²)	1.01	0.98–1.05	0.37	1.05	1.02–1.09	0.003
Hypertension	1.09	0.51–2.33	0.82	0.87	0.36–2.10	0.75
Diabetes	1.05	0.42–2.60	0.92	0.71	0.26–1.95	0.51
Smoking	1.43	0.68–3.03	0.35	1.39	0.59–3.31	0.45
Bleeding
Etiology^a)
OSA	0.78	0.28–2.22	0.65	0.99	0.28–3.53	0.98
CLD	0.80	0.16–4.01	0.79	0.79	0.15–4.13	0.78
Age (1=1 yr)	1.00	0.97–1.04	0.79	1.00	0.96–1.05	0.85
Male	1.16	0.40–3.30	0.79	1.34	0.40–4.45	0.64
BMI (1=1 kg/m²)	0.97	0.91–1.03	0.34	0.96	0.89–1.04	0.34
Hypertension	1.02	0.38–2.70	0.97	1.07	0.31–3.61	0.92
Diabetes	1.21	0.39–3.71	0.75	1.59	0.44–5.75	0.48
Smoking	0.84	0.31–2.28	0.73	0.75	0.25–2.24	0.60
All-cause mortality
Etiology^a)
OSA	0.06	0.01–0.51	0.009	0.01	0.0002–0.55	0.024
CLD	0.81	0.22–3.00	0.75	0.79	0.18–3.55	0.76
Age (1=1 yr)	1.07	1.02–1.11	0.003	1.06	1.01–1.12	0.025
Male	0.41	0.14–1.21	0.11	1.25	0.30–5.16	0.76
BMI (1=1 kg/m²)	1.01	0.97–1.06	0.63	1.11	1.03–1.20	0.009
Hypertension	1.22	0.41–3.65	0.73	0.34	0.08–1.39	0.13
Diabetes	1.28	0.35–4.68	0.71	1.11	0.24–5.11	0.90
Smoking	1.03	0.34–3.15	0.96	0.81	0.16–4.04	0.79

^a)Reference group is polycythemia vera.

Abbreviations: aHR, adjusted hazard ratio; BMI, body mass index; CI, confidence interval; CLD, chronic lung disease; HR, hazard ratio; OSA, obstructive sleep apnea.

Blood Res 2021;56:166~174 https://doi.org/10.5045/br.2021.2021111