Univariable and multivariable analysis for comorbidities associated with overall survival in the development cohort.
Variables | N | Univariable analysis | Multivariable analysis | ||
---|---|---|---|---|---|
1-year OS rate (95% CI) | Hazard ratio (95% CI) | ||||
Age | <0.001 | ||||
<50 years | 2,245 | 71.8 (69.9–73.8) | 1 | ||
50–64 years | 1,438 | 64.1 (61.5–66.7) | 1.228 (1.107–1.362) | <0.001 | |
≥65 years | 126 | 48.1 (39.6–58.4) | 1.733 (1.340–2.232) | <0.001 | |
Sex | <0.001 | ||||
Female | 1,754 | 69.1 (66.9–71.3) | 1 | ||
Male | 2,055 | 67.4 (65.3–69.6) | 1.142 (1.038–1.255) | <0.001 | |
Previous non-hematologic malignancy | 0.002 | ||||
No | 3,422 | 69.1 (67.5–70.7) | 1 | ||
Yes | 387 | 60.3 (55.4–65.6) | 1.182 (1.015–1.376) | 0.031 | |
Hypertension | <0.001 | ||||
No | 2,585 | 70.8 (69.0–72.6) | 1 | ||
Yes | 1,224 | 62.6 (59.8–65.5) | 1.141 (1.026–1.268) | 0.015 | |
Diabetes | 0.005 | ||||
No | 2,684 | 69.2 (67.4–71.0) | 1 | ||
Yes | 1,125 | 65.7 (62.9–68.7) | 1.002 (0.899–1.117) | 0.965 | |
Dyslipidemia | 0.007 | ||||
No | 1,674 | 70.1 (67.9–72.4) | 1 | ||
Yes | 2,135 | 66.6 (64.5–68.7) | 1.036 (0.937–1.144) | 0.486 | |
Chronic obstructive pulmonary disease | 0.21 | ||||
No | 3,618 | 68.4 (66.8–70.0) | NA | ||
Yes | 191 | 64.3 (57.4–71.9) | NA | ||
Cerebrovascularor cardiovascular disease | <0.001 | ||||
No | 3,643 | 68.8 (67.2–70.4) | 1 | ||
Yes | 166 | 54.1 (46.6–62.9) | 1.498 (1.212–1.848) | <0.001 | |
Anxiety disorder and/or depression | 0.006 | ||||
No | 3,501 | 68.8 (67.2–70.4) | 1 | ||
Yes | 308 | 60.8 (55.4–66.8) | 1.176 (0.996–1.386) | 0.055 |
Abbreviations: CI, confidence interval; NA, not available; OS, overall survival.