Table 3

Univariable analysis of factors predictive for OS.

Characteristic	All BCR-ABL1-positive ALL patients			Transplanted BCR-ABL1-positive ALL patients
Characteristic	3-year OS (%)		P	3-year OS (%)		P
Age group
AYA	39.0		0.064	52.9		0.690
Adult and elderly	19.6		0.064	55.0		0.690
Sex
Male	33.6		0.876	54.2		0.906
Female	26.8		0.876	52.9		0.906
WCC at diagnosis
>30×10⁹/L	25.5		0.585	52.3		0.684
<30×10⁹/L	35.9		0.585	63.6		0.684
MRD status (%)	≥0.1	<0.1		≥0.1	<0.1
TP1	36.7	36.1	0.974
TP2	23.5	53.1	0.077
TP3	11.5	65.4	0.005	25.0	73.9	0.003
Chemotherapy
GMALL/BFM	25.7		0.081
Hyper-CVAD	33.7		0.081
TKI
Yes (2012–2018)	33.7		0.390
No (2006–2011)	23.5		0.390
Transplant
Yes	58.9		<0.001
No	10.6		<0.001
Disease status at transplant
CR1	65.9		0.003
CR>1	16.7

Significant P-value <0.05.

Abbreviations: ALL, acute lymphoblastic leukemia; AYA, adolescent and young adult; CR, complete remission; MRD, measurable residual disease; OS, overall survival; TKI, tyrosine kinase inhibitor; TP1, timepoint 1; TP2, timepoint 2; TP3, timepoint 3; WCC, white cell count.

Blood Res 2021;56:175~183 https://doi.org/10.5045/br.2021.2021045