Fig. 1. PRAME transcript expression in MM patients during chemotherapy.
RNA samples collected from patients MM1, 4, and 6 at diagnosis and during treatment were analyzed for
PRAME expression using the
PRAME/
ABL qRT-PCR assay. The normalized ratios were plotted along with the previously collected normalized
MAGEC1 data [
21] and serum M and Sb2M levels. *Indicates patient death within three months of the last data point; C+D, cyclophosphamide/dexamethasone cycles; M+P, melphalan/prednisone cycles; R, localiszd radiation; open circles indicate a lack of detectable transcripts at a sensitivity level determined by the corresponding
ABL Cq.