Specification of the diagnostic value of the Wells criteria and D-Dimer level for PE detection.
Variables | Clinical probability of PEa) | Cut-off | Sen. | Spec. | PPV | NPV | AUC | |
---|---|---|---|---|---|---|---|---|
Wells score | Total | 3 | 75.00 | 35.87 | 9.2 | 94.3 | 0.557 | 0.497 |
D-dimer, mg/L | Total | 1,447 | 87.50 | 63.04 | 17.1 | 98.3 | 0.735 | 0.003 |
PE unlikely (N=67) | 1,447 | 83.33 | 65.57 | 19.2 | 97.6 | 0.730 | 0.019 | |
PE likely (N=33) | 1,962 | 99.00 | 78.12 | 22.2 | 99.0 | 0.781 | <0.001 |
a)Based on Wells score.
Abbreviations: AUC, area under the curve; NPV, negative predictive value; PE, pulmonary embolism; PPV, positive predictive value; Sen., sensitivity; Spec., specificity.