Table 3

Bleeds needed for hospitalization and used amount of CFCs.

	Mean age (yr)	Severity (N of cases)	N of case	Hospitalized days (day)	Amount of CFCs per kg (IU/kg)
	Mean age (yr)	Severity (N of cases)	N of case	Hospitalized days (day)	Total	First 3ds	After 3ds
Major bleeds
CNS bleed	26.3±20.1	S 5	10	36.27±59.4	579.5±494.0	213.7±114.9	202±176.4
CNS bleed	26.3±20.1	M 5	10	36.27±59.4	579.5±494.0	213.7±114.9	202±176.4
GI bleed	45.3±12.2	S 2	17	5.6±2.6	975.2±714.1	191.4±103.5	77.9±74.3
		M 13
		m 2
Iliopsoas bleed	25.1±13.2	S 4	7	11.3±13.1	473.1±300.6	179.6±160.1	188.2±129.9
Iliopsoas bleed	25.1±13.2	M 3
Compartment syndrome	42±1.4	S1	2	19.0±16.9	353.0±79.2	188.2±129.9	98.5±25.7
Compartment syndrome	42±1.4	M 1
Opthalmic hemorrhage^a)	32.9±9.1	S 3	7	8.6±4.7	488.1±481.2	152.0±120.6	135.3±128.9
Opthalmic hemorrhage^a)	32.9±9.1	M 4
Major bleeds total/average	35.1±2.7	S 15	43	15.4±9.98	460.3±66.4	187.2±114.8	142.7±139.6
		M 26
		m 2
Moderate bleeds
Dental bleed	22.8±17.7	S 5	12	3.2±1.6	127.2±79.2	121.3±68.7	-
Dental bleed	22.8±17.7	M 7	12	3.2±1.6	127.2±79.2	121.3±68.7	-
Joint bleed	32.0±21.7	S 8	14	9.1±7.7	359.2±300.8	262.2±208.9	107.1±95.5
Joint bleed	32.0±21.7	M 6
Intramuscular bleed^b)	28.9±23.4	S 5	9	8.2±6.9	524.7±513.7	181.7±59.8	96.7±86.1
Intramuscular bleed^b)	28.9±23.4	M 4
Large ecchymosis	15.4±7.1	S 5	5	5.6±3.05	214.2±154.0	136.2±71.7	74.4±72.1
Moderate bleeds total/average	26.8±3.1	S 23	40	6.7±6.1	334.4±54.9	183.3±145.0	68.5±60.7
Moderate bleeds total/average	26.8±3.1	M 17
P^c)	0.30			0.021	0.042	0.885	0.021

^a)Vitreous hemorrhage, Hematoma of eyeball. ^b)Intramuscular bleed, excluding: iliopsoas bleed. ^c)P-value less than 0.05 is regarded as statistically significant in comparison with Major and moderate bleeds.

Abbreviations: m, mild hemophilia A; M, moderate hemophilia A; S, severe hemophilia A.

Blood Res 2021;56:141~149 https://doi.org/10.5045/br.2021.2020289