Hematologic and non-hematologic toxicities (worst during treatment).
| Toxicity | None | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Any (%) | Grade 3/4 (%) |
|---|---|---|---|---|---|---|---|
| Hematologic | |||||||
| Neutropenia | 7 | 1 | 1 | 13 | 9 | 24 (77.4) | 22 (71.0) |
| Lymphopenia | 20 | 5 | 3 | 3 | 0 | 8 (25.8) | 3 (9.7) |
| Thrombocytopenia | 11 | 9 | 3 | 3 | 5 | 20 (64.5) | 8 (25.8) |
| Febrile neutropenia | 28 | -a) | -a) | 3 | 0 | 3 (9.7) | 3 (9.7) |
| Non-hematologic | |||||||
| Pruritus | 16 | 8 | 5 | 2 | 0 | 15 (48.4) | 2 (6.5) |
| Fatigue | 17 | 12 | 2 | 0 | 0 | 14 (45.2) | 0 |
| Rash | 22 | 5 | 0 | 4 | 0 | 9 (29.0) | 4 (12.9) |
| Diarrhea | 26 | 3 | 2 | 0 | 0 | 5 (16.2) | 0 |
| Dyspepsia | 28 | 1 | 2 | 0 | 0 | 3 (9.7) | 0 |
| Constipation | 29 | 2 | 0 | 0 | 0 | 2 (6.5) | 0 |
| Headache | 30 | 0 | 1 | 0 | 0 | 1 (3.2) | 0 |
| Insomnia | 30 | 0 | 1 | 0 | 0 | 1 (3.2) | 0 |
| Deep vein thrombosis | 30 | 0 | 1 | 0 | 0 | 1 (3.2) | 0 |
| Dyspnea | 30 | 1 | 0 | 0 | 0 | 1 (3.2) | 0 |
| Tongue discoloration | 30 | 1 | 0 | 0 | 0 | 1 (3.2) | 0 |
| Loss of appetite | 30 | 1 | 0 | 0 | 0 | 1 (3.2) | 0 |
| Increased creatinine | 30 | 0 | 1 | 0 | 0 | 1 (3.2) | 0 |
a)Grade 1 or 2 febrile neutropenia is not defined in the Common Toxicity Criteria for Adverse Events v5.0.
Blood Res 2021;56:102~108 https://doi.org/10.5045/br.2021.2021086
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