Fig. 2. MAPK pathway mutations in LCH. Activating MAPK pathway mutations in LCH drive pathologic ERK activation.
Abbreviations: A-Raf, rapidly accelerated fibrosarcoma isoform A; B-Raf, rapidly accelerated fibrosarcoma isoform B; C-Raf, rapidly accelerated fibrosarcoma isoform C; ERK, extracellular signal-regulated kinase; GPCR, G-protein-coupled receptor; LCH, Langerhans cell histiocytosis; MAPK, mitogen-activated protein kinase; MEK, mitogen-activated protein kinase kinase; Ras, rat sarcoma.

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