Diagnostic criteria for chronic myelomonocytic leukemia according to the 2016 World Health Organization classification.
| Diagnostic criteria for CMML | ||
|---|---|---|
|
Persistent monocyte increases in PB; ≥1×109/L and ≥10% of leukocytes. Exclusion of BCR-ABL-positive chronic myeloid leukemia, primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Blasts are <20% in PB and BM. Dysplasia in at least 1 myeloid lineage If dysplasia is not present, at least 1 of the following criteria should be present: - Acquired clonal cytogenetic or molecular abnormality in hematopoietic cells - Persistent monocytosis ≥3 months with exclusion of other causes |
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| Subcategory | ||
| According to blast % and promonocytes in PB and BM | CMML-0 | <2% blasts in PB and <5% blasts in BM; no Auer rods |
| CMML-1 | 2–4% blasts in PB or 5–9% blast in BM; <5% blasts in PB; <10% blast in BM; no Auer rods | |
| CMML-2 | 5–19% blasts in PB; 10–19% blasts in BM or presence of Auer rods; <20% blasts in PB and BM | |
| According to WBC counts in PB | Dysplastic type | WBCs in peripheral blood <13×109/L |
| Proliferative type | WBCs in peripheral blood ≥13×109/L | |
Abbreviations: BM, bone marrow; CMML, chronic myelomonocytic leukemia; PB, peripheral blood; WBC, white blood cell.