Table 1

Clinical and pathological review of seven cases of acute myelofibrosis with acute lymphoblastic leukemia reported in the literature.

S. No	Author, year	Age/sex	HSM, LN	Initial PB findings	BMA findings	ALL subtype	BM biopsy findings	Cytogenetic findings	MF at repeat BM	Outcome
1	Amjad et al. [2], 1979^a,b)	57 yr/F	Absent	Anaemia	Dry tap	NA	MF	Normal	NA	Death
2	Chen et al. [3], 1992^a)	4 yr/M	NA	NA	NA	NA	NA	NA	NA	NA
3	Dunphy et al. [4], 1996^a)	44 yr/M	Absent	Pancytopenia	Dry tap	Pre-B	MF, pleomorphic and dysplastic megs	Deletion 5p	Present(EOM)	Alive
4	Abla et al.[5], 2006	15 yr/F	Absent	Bicytopenia,7% blasts	Diluted 9–58% blasts	Pre-B	MF (reticulin and collagen), blasts	Normal	NA	Alive
5	Avci et al. [6], 2008	4.5 yr/M	Absent	Bicytopenia, 3% blasts	Dry tap	Pre-B	MF	Extra signal of chr.21q22	Absent (day-70)	Alive
5	Avci et al. [6], 2008	4.5 yr/M	Absent	Bicytopenia, 3% blasts	Dry tap	CD20+	MF	Extra signal of chr.21q22	Absent (day-70)	Alive
6	Gonzalez et al. [7], 2013^c)	72 yr/M	NA	Pancytopenia	Dry tap	Pre-B	MF, clustering and dysplasia of megs, reduced megs	NA	NA	Relapse, Alive
6	Gonzalez et al. [7], 2013^c)	72 yr/M	NA	Pancytopenia	Dry tap	CD20+	MF, clustering and dysplasia of megs, reduced megs	NA	NA	Relapse, Alive
7	Friesenbichler et al. [8], 2018	13 yr/F	Absent	Pancytopenia	Hypocellular	Pre-B	MF, megs hyperplasia and dysplasia, 15% blasts	Normal	Absent (day-33)	Alive
7	Friesenbichler et al. [8], 2018	13 yr/F	Absent	Pancytopenia	Hyperplastic and dysplastic megs, no blasts	Pre-B	MF, megs hyperplasia and dysplasia, 15% blasts	Normal	Absent (day-33)	Alive

^a)Acute myelofibrosis preceded the diagnosis of ALL. ^b)Patient presented with recurrent anaemia. Initial PB examination did not show blasts. Subsequently, blasts were observed in PB. ^c)Patient was a treated case of multiple myeloma.

Abbreviations: ALL, acute lymphoblastic leukemia; BM, bone marrow; BMA, bone marrow aspiration; EOM, end of maintenance; F, female; HSM, hepatosplenomegaly; LN, lymphadenopathy; M, male; Megs, megakaryocytes; MF, myelofibrosis; NA, not available; PB, peripheral blood.

Blood Res 2021;56:46~50 https://doi.org/10.5045/br.2021.2020160