Frequency and spectra of chromosomal aberrations according to the type of acute leukemia and detection method in all patients using conventional cytogenetics, including FISH.
| Chromosomal aberration by conventional cytogenetics | Fusion transcript | AML | ALL | MPAL | Total | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| K | F | K | F | K | F | ||||||
| t(15;17)(q24;q21) | 54 | 13 | 67 | ||||||||
| t(9;22)(q34;q11) | 3 | 4 | 22 | 8 | 4 | 41 | |||||
| t(8;21)(q22;q22) | 36 | 36 | |||||||||
| 11q23 | |||||||||||
| t(4;11)(q21;q23) | 1 | 1 | |||||||||
| t(6;11)(q27;q23) | 5 | 5 | |||||||||
| t(11;19)(q23;p13.3) | 0 | ||||||||||
| t(9;11)(p22;q23) | 6 | 1 | 7 | ||||||||
| t(10;11)(p12;q23) | 4 | 1 | 5 | ||||||||
| t(11;19)(q23;p13.3) | 1 | 1 | |||||||||
| t(12;21)(p13;q22) | 5 | 7 | 12 | ||||||||
| t(1;19)(q23;p13) | 1 | 1 | |||||||||
| inv(16)(p13;q22) | 21 | 1 | 22 | ||||||||
| t(9;9)(q34;q34) | 0 | ||||||||||
| del(1p32) | 0 | ||||||||||
| t(16;21)(p11;q22) | 2 | 2 | |||||||||
| t(6;9)(p23;q34) | 2 | 2 | |||||||||
| Extra-aberrationa) | 113 | 5 | 43 | 7 | 2 | 170 | |||||
| Positive cases excluding extra-aberration | 151 | 46 | 5 | 202 | |||||||
| Positive cases | 269 | 96 | 7 | 372 | |||||||
| Total cases | 521 | 187 | 9 | 717 | |||||||
| Cases of ‘NT’ | 15 | 12 | 0 | 27 | |||||||
| Cases excluding ‘NT’ | 506 | 175 | 9 | 690 | |||||||
| Positive cases excluding ‘extra-aberration’ & ‘NT’ (%) | 30 | 26 | 56 | 29 | |||||||
| Positive cases excluding ‘NT’ (%) | 53 | 55 | 78 | 54 | |||||||
a)Extra-aberrations are the numerical abnormalities or structural rearrangements, excluding 28 fusion transcripts of the multiplex RT-PCR system.
Abbreviations: F, fluorescence
Blood Res 2020;55:225~245 https://doi.org/10.5045/br.2020.2020255
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