Patients who received stem cell transplantation.
Patient 1 | Patient 2 | Patient 3 | |
---|---|---|---|
Age at diagnosis (yr)/sex | 14/F | 7/M | 8/M |
Immunophenotype | B-cell | T-cell | T-cell |
Stage | III | II | IV |
CNS involvement | None | None | None |
Initial Chemotherapy | POG-9404 | COG-1901 | COG-1901 |
Reason of transplantation | Relapse (mediastinum, kidney) | Relapse (mediastinum) | Initial extensive stage (BM, mediastinum), poor response |
Treatment after relapse | POG-9406, mediastinal radiotherapy | ICE protocol | - |
Type of transplantation | Autologous PBSCT | Autologous PBSCT | Matched sibling donor PBSCT |
Conditioning regimen | TBI/Cy/VP16 | Bu/Cy/VP16 | TBI/Cy/rATG |
Local radiotherapy | Mediastinum (post-PBSCT) | PCRT mediastinum (post-PBSCT) | - |
Current status | Death due to relapsed disease (post-PBSCT 4 mo) | Alive without disease (1 yr 5 mo) | Alive without disease (7 mo) |
Abbreviations: BM, bone marrow; CNS, central nervous system; COG, children’s oncology group; Cy, cyclophosphamide; ICE, ifosfamide, carboplatin, etoposide; PBSCT, peripheral blood stem cell transplantation; PCRT, prophylactic cranial radiotherapy; POG, Pediatric Oncology Group; rATG, rabbit anti-thymocyte globulin; TBI, total body irradiation; VP16, etoposide.