Information of study drug administration.
| Treatment type | Treatment dose (IU), mean±SD | Treatment dose (IU/kg), mean±SD | N (%) |
|---|---|---|---|
| Treatment of bleeding (on-demand) | 36 (63.2) | ||
| Total | 32,241.7±39,659.9 | 482.3±486.1 | |
| Average | 2,831.5±1,341.2 | 43.8±14.4 | |
| Surgery and/or perioperative coverage | 2 (3.5) | ||
| Total | 44,040.0±2,658.7 | 630.4±25.7 | |
| Average | 3,145.7±189.9 | 45.0±1.8 | |
| Prophylaxis | 45 (78.9) | ||
| Total | 2,388,776.9±4,020,208.1 | 33,712.0±51,060.2 | |
| Average | 2,603.5±881.7 | 41.9±11.1 | |
Treatment of bleeding and surgery and/or preoperative coverage: Total treatment dose (IU/kg)=sum of total dose per infusion for each treatment regimen/body weight Average treatment dose (IU/kg)=(total treatment dose for each treatment regimen/body weight)/Total number of infusions for each treatment regimen
Prophylaxis: Total treatment dose (IU/kg)=sum of [(total number of infusions)×(total dose per infusion/body weight)] ✓ Total number of infusions=(actual Dosing interval)×integer of {(stop date of treatment regimen-start date of treatment regimen+1)/7} +[7×decimal of {(stop date of treatment regimen-start date of treatment regimen+1)/7}]/(dosing interval) ✓ Actual dosing interval=stop date of treatment regimen-start date of treatment regimen Average treatment dose (IU/kg)=(total treatment dose/body weight)/total number of infusions
Abbreviations: IU, international unit; SD, standard deviation.