Baseline parameters of CLL patients (N=52).
Male, N (%) | 35 (67.3%) |
Female, N (%) | 17 (32.7%) |
Male:female | 2:1 |
Median age (range), yr | 65 (43–88) |
<60 yr, N (%) | 15 (28.8%) |
≥60 yr, N (%) | 37 (71.2%) |
Incidental lymphocytosis | 9 (17%) |
Fatigue | 19 (37%) |
B-symptoms | 7 (13.5%) |
Hepatomegaly | 14 (27.0%) |
Splenomegaly, N (%) | 20 (38.5%) |
Lymphadenopathy, N (%) | 28 (53.8%) |
<3 groups involved | 09 (32.1%) |
3 or more groups involved | 19 (67.9%) |
ECOG performance status | |
0, N (%) | 16 (30.8%) |
1, N (%) | 28 (53.8%) |
2/3, N (%) | 08 (15.4%) |
Hemoglobin, median (g/dL) | 12.4 (5.0–16.6) |
Total leucocyte count, median (×109/L) | 57.7 (18.0–307.8) |
Absolute lymphocyte count, median (×109/L) | 52.0 (7.6–292.4) |
Platelet count, median (×109/L) | 176.5 (46.0–449.0) |
Smudge cells, median (%) | 32 (5–126) |
Lactate dehydrogenase (LDH) (U/L) | |
Within normal range, N (%) | 31 (59.6%) |
Elevated (>1×upper limit of normal), N (%) | 16 (30.8%) |
Missing data, N (%) | 5 (9.6%) |
β2-microglobulin (mg/L), median | 4.7 (0.89–16.5) |
Within normal range, N (%) | 4 (7.7%) |
Elevated, N (%) | 27 (51.9%) |
Missing data, N (%) | 21 (40.4%) |
Modified Rai stage | |
Low, N (%) | 16 (30.8%) |
Intermediate, N (%) | 23 (44.2%) |
High, N (%) | 13 (25.0%) |
Binet stage | |
A, N (%) | 29 (55.8%) |
B, N (%) | 10 (19.2%) |
C, N (%) | 13 (25.0%) |
Atypical immunophenotypic features in different combinations identified in the study cohort | |
CD23 weak or absent expression, N (%) | 7 (13.5%) |
Bright CD20 expression, N (%) | 5 (9.6%) |
Bright expression of SIgλ/SIgκ, N (%) | 12 (23.1%) |