Characteristics and clinical features of polycythemia vera patients with and without pulmonary hypertension.
| With PH (N=9) | Without PH (N=74) | ||
|---|---|---|---|
| Age (yr), median (range) | 71 (42–85) | 61.5 (26–91) | 0.049 |
| Gender, male:female | 2:7 | 49:25 | 0.010 |
| Laboratory findings, mean±SD | |||
| WBC (×109/L) | 17.2±7.5 | 14.5±7.4 | 0.330 |
| Monocyte (×109/L) | 0.9±0.3 | 0.7±0.4 | 0.200 |
| Hemoglobin (g/dL) | 15.9±2.6 | 18.4±2.6 | 0.010 |
| Platelet (×109/L) | 616.6±284.2 | 437.7±191.7 | 0.020 |
| LDH (×UNL) | 1.3±0.3 | 1.3±0.5 | 0.973 |
| Driver gene mutations, N (%) | |||
| 8 (88.9) | 59 (79.7) | 0.396 | |
| 0 (0) | 3 (4.1) | - | |
| Comorbidity, N (%) | |||
| Diabetes mellitus | 2 (22.2) | 20 (27.0) | 0.556 |
| Hypertension | 6 (66.7) | 44 (59.5) | 0.486 |
| Chronic kidney disease | 4 (44.4) | 24 (32.4) | 0.355 |
| Smoking | 2 (22.2) | 42 (43.2) | 0.266 |
| Thrombotic eventsa) | 2 (22.2) | 22 (29.7) | 0.723 |
| Follow-up duration (yr), median (range) | 2.5 (0.1–20.4) | 6.3 (0.1–25.5) | 0.298 |
a)Overall thrombotic events (before, at the time of, and after diagnosis).
Abbreviations: LDH, lactate dehydrogenase; PH, pulmonary hypertension; UNL, upper normal limit.
Blood Res 2020;55:77~84 https://doi.org/10.5045/br.2020.2020001
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