Severity of bleeding episodes was defined as “mild,” little or no pain, little or no change in the range of motion of the affected joint, and mild restriction of mobility and activity; “moderate,” mild or moderate pain, some decrease in range of movement of the affected joint, and moderate decrease in mobility and activity; and “severe,” significant pain, substantial decrease in the range of motion of the affected joint, incapacity, and life-threatening.

Abbreviation: NA, not applicable.