^a)Ibrutinib is not approved in Japan for WM. ^b)Data relapsed/refractory WM.

Abbreviations: R, rituximab; DRC, dexamethasone, R, cyclophosphamide; R-CHOP, R, cyclophosphamide, hydroxyl-doxorubicin, vincristine, prednisone; BDR, bortezomib, dexamethasone, R; ORR, overall response rate; JPY, japanese yen; PFS, progression-free survival; TTF, time to treatment failure; TTP, time to progression; PD, progressive disease; NA, not applicable; NR, not reached.