Improvement of anemia after eculizumab. In both patients with PNH/AA and classic PNH, hemoglobin levels were significantly improved after the first 6 months of eculizumab treatment; the effect (hemoglobin above 10 g/dL) was sustained after 36 months. P-values compared with baseline were assessed by Wilcoxon signed-rank test.

Abbreviations: AA, aplastic anemia; ecu, eculizumab; PNH, paroxysmal nocturnal hemoglobinuria.