Patent specific iPSC disease modeling and cell based transplantation therapy. Mononuclear cells from patient are used for generating iPSC. Depending on the source of cells, both memory contained cells such as mature blood cell and memory lacking immature cell mediated iPSC are generated. Subsequent differentiation from patient specific iPSC can be directly used for personalized cell based therapy with proper cell lineages such as blood, muscle, and neuron. Gene editing technology such as ZFN, TALEN, and CRISPR will be utilized to fix the genetic error from affected patients even with large DNA deletions. Also, patient iPSC based personalized medicine to find right dosage of known medications or novel therapeutic agents can be tested.