^a)The number of injection increased from 3 times a week to every day.

Abbreviations: CED, cumulative exposure days to FVIII; ID, inhibitor detection; ITI, immune tolerance induction; Int22inv., intron 22 inversion; Exon del, exon deletion; UK, unknown; HP, historical peak; FVIII, factor VIII; Pd, plasma-derived FVIII/von Willebrand factor; R, recombinant; CT, complete tolerance; PT, partial tolerance; F, failure.