Blood Res  
Evaluating the effect of donor anxiety levels and lifestyle characteristics on the activation of platelet concentrates
Soner Yılmaz,1 İbrahim Eker,2 Elif Elçi,3 Aysel Pekel,4 Riza Aytaç Cetinkaya,5 Aytekin Unlu,6 Cengizhan Açıkel,7 and Ismail Yaşar Avci8
1Regional Blood Center, Health Science University, Gulhane Training and Education Hospital, Ankara, 2Department of Pediatric Hematology, Afyon Kocatepe University, Afyon, 3Department of Hematology, Health Science University, 4 Department of Allergy and Immunology, Health Science University, Gulhane Training and Education Hospital, Ankara, 5Department of Infectious Disease, Health Science University, Sultan Abdulhamid Han Training and Education Hospital, Istanbul, 6Department of General Surgery, Health Science University, Gulhane Training and Education Hospital, Ankara, Turkey, 7Clinical Research International Ltd, Cologne, Germany, 8Department of Infectious Disease and Clinical Microbiology, Health Science University, Gulhane Training and Education Hospital, Ankara, Turkey
Correspondence to: Soner Yılmaz, M.D.
Health Science University, Gulhane Training and Education Hospital, Regional Blood Center, Ankara 06018, Turkey
E-mail: drsoneryilmaz@gmail.com
Published online: December 2, 2019.
© The Korean Journal of Hematology. All rights reserved.

Abstract
Background: Smoking, alcohol use, performing regular physical exercise, dietary habits, and anxiety level may cause platelet activation. We aimed to evaluate the anxiety levels, smoking status, alcohol intake, and sportive habits of donors, and determine their impact on the quality of apheresis-platelets.
Methods: State and Transient Anxiety Inventory (STAI) was used to determine the level of donors' anxiety. STAI has two subscales: S-anxiety scale (STAI-I) and T-anxiety scale (STAI-II), each comprising 20 questions rated on a 4-point Likert scale. Data on smoking, alcohol consumption, and performing regular physical exercise were obtained from a questionnaire filled out before donation. Flow cytometric analysis was used to quantify activated platelets.
Results: The STAI-I level of 86 participants was normal, while that of 12 was higher. No significant difference was found in the active platelet absolute count [1.8×1011(2.7) and 1.4×1011(1.3), respectively; P=0.665] between donors with normal STAI-I levels and those with higher STAI-I levels. Of 98 donors, 42 had normal STAI-II levels, while 56 had higher STAI-II levels. No significant difference was found in the active platelet absolute count [2.3×1011(3.1) and 1.5×1011(2.3), respectively; P=0.224] between donors with normal STAI-II levels and those with higher STAI-II levels. Platelet counts of individuals who perform regular physical exercise were significantly higher than those of individuals who did not perform regular physical exercise (6.3±1.4×1011 vs. 5.5±1.4×1011).
Conclusion: The quality of apheresis platelets is not affected by anxiety levels and lifestyle characteristics of blood donors. There is no need to organize an apheresis blood donor pool for these patients.
Keywords: Platelet, Apheresis, Anxiety


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