Blood Res 2019; 54(3): 163-163  https://doi.org/10.5045/br.2019.54.3.163
A case of follicular lymphoma accompanied with chylous ascites
Masashi Ohe1, Masaru Baba1, Haruki Shida1, Ken Furuya1, Katsuhisa Kogawa2
1Department of Internal Medicine, JCHO Hokkaido Hospital, 2Department of Hematology, Sapporo Kyoritsu Gorinbashi Hospital, Sapporo, Japan
Correspondence to: Masashi Ohe, M.D., Ph.D., Department of Internal Medicine, JCHO Hokkaido Hospital, 1-8-3-18 Nakanoshima, Toyohira-ku, Sapporo 062-8618, Japan, E-mail: oektsp1218@sweet.ocn.ne.jp
Received: April 26, 2019; Accepted: May 29, 2019; Published online: September 30, 2019.
© The Korean Journal of Hematology. All rights reserved.

cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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A 71-year-old woman was admitted to our hospital for further examination of massive ascites. The lactate dehydrogenase level was 230 IU/L, and the serum soluble interleukin-2 receptor level was 4,296 U/mL (reference range, 122–496 U/mL). Computed tomography revealed bilateral cervical and abdominal lymphadenopathy accompanied with massive ascites (A). Biopsy specimens obtained from cervical lymph nodes showed well-circumscribed follicles, with a monotonous population of lymphocytes, which was positive for CD10/20 and BCL2. Paracentesis revealed creamy opaque fluid (B), with elevated triglyceride (987 mg/dL), which is referred to as chylous ascites (CA). Cytological examination of CA showed lymphocytes with round nucleus and almost invisible cytoplasm and lymphocytes with lobulated nucleus and slightly visible cytoplasm (C). Flow cytometry showed many T lymphocytes expressing CD3/5 and a few B lymphocytes expressing CD10/20. Fluorescence in situ hybridization of CA confirmed IgH/BCL2 gene fusion (D). Based on these results, the patient was diagnosed with follicular lymphoma (FL) accompanied with CA, including a peritoneal lesion. Although ascites is common in lymphoma, CA is rare, and a few cases of FL accompanied with CA have been reported.



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