Blood Res 2019; 54(1): 52-56
Analysis of hematologic parameters of donors, patients, and granulocyte concentrates to predict successful granulocyte transfusion
Jong-Mi Lee1, Seung Jun Choi1, Hoon Seok Kim1, Mina Yang1, Yonggoo Kim1, Jong Wook Lee2, Jihyang Lim1
Departments of 1Laboratory Medicine and 2Hematology, College of Medicine, The Catholic University of Korea, Seoul, Korea
Correspondence to: Jihyang Lim, M.D., Ph.D. Department of Laboratory Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 06591, Korea, E-mail:
Received: August 7, 2018; Revised: October 2, 2018; Accepted: October 19, 2018; Published online: March 31, 2019.
© The Korean Journal of Hematology. All rights reserved.

cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Granulocyte transfusion (GTx) is performed as a supportive therapy in severe neutropenic patients caused by various conditions. The study aimed to analyze the hematologic parameters of donors, patients, and granulocyte concentrates to predict successful GTx.

This study was performed in 281 donors, with their granulocyte concentrates being collected through apheresis, and in 54 severe neutropenic patients who had various hematologic diseases. Complete blood cell counts of donors pre- and post-apheresis, granulocyte concentrates, and patients pre- and post-GTx were analyzed. Patients were divided into two groups according to survival at discharge (Group S, survival; Group D, dead) to compare various factors including age, infection status, pre- and post-GTx total white blood cell counts (TWBCC) and absolute neutrophil counts (ANC), total number of GTx, infused TWBCC and ANC per weight, and use of G-CSF during therapy.

Overall data of patients showed that both TWBCC and ANC were significantly increased after GTx (median values at pre-GTx, TWBCC=0.40×109/L, ANC=0.14×109/L; post-GTx, TWBCC=0.57×109/L, ANC=0.29×109/L, both P<0.0001). After GTx, Group S (N=25) showed significantly higher TWBCC and ANC than Group D (N=29) (P=0.01 and P=0.04, respectively). Using different cutoff levels, post-GTx TWBCC greater than 0.5×109/L showed statistically significant difference between the two groups (P<0.01). None of the other factors showed statistically significant differences.

The TWBCC and ANC after GTx were significant factors to predict patients’ outcome. Therefore, follow-up of those two parameters may be helpful to select or consider other therapeutic modalities including additional GTx.
Keywords: Granulocyte transfusion, Neutropenia, Total white blood cell counts, Absolute neutrophil counts, Granulocyte colony-stimulating factor


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