Blood Res 2018; 53(3): 227-232
The incidence of venous thromboembolism is not lowin Korean patients with advanced pancreatic cancer
Seug Yun Yoon1, Min-Young Lee1, Jina Yoon2, Han Jo Kim3, Kyoung-Ha Kim1, Se Hyung Kim2, Sang-Cheol Lee3, Sang Byung Bae3, Chan-Kyu Kim2, Nam-Su Lee1, Kyu Taek Lee3, Sung Kyu Park2, Dae Sik Hong2, Jong-Ho Won1
Division of Hematology & Oncology, Department of Internal Medicine, Soonchunhyang University, College of Medicine, 1Seoul Hospital, Seoul, 2Bucheon Hospital, Bucheon, 3Cheonan Hospital, Cheonan, Korea
Correspondence to: Jong-Ho Won, M.D., Ph.D.Division of Hematology & Oncology, Department of Internal Medicine, Soonchunhyang University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul 04401, Korea E-mail:
Received: November 2, 2017; Revised: June 6, 2018; Accepted: June 26, 2018; Published online: September 30, 2018.
© The Korean Journal of Hematology. All rights reserved.

cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pancreatic cancer is among the most common malignancies associated with venous thromboembolism (VTE). Asian patients are known to have a lower incidence of VTE compared to Caucasian patients. However, few studies have investigated the incidence of VTE in Asian patients with pancreatic cancer.
This retrospective review of medical records was performed on 505 patients with histopathologically proven advanced stage pancreatic cancer, from January 2006 to December 2012, at Soonchunhyang University Hospitals.
Ninety-four patients (18.6%) had at least one pulmonary embolism (PE), deep vein thrombosis (DVT), or splanchnic vein thrombosis (SVT); 38 patients had isolated SVT; and 56 patients (11.1%) had at least one classic VTE (PE and/or DVT of lower extremities). Patients with more advanced stages of pancreatic cancer (distant metastatic stage, recurrence) or who had received chemotherapy had a higher incidence of classic VTE. Patients who were simultaneously diagnosed with pancreatic cancer and classic VTE had a poorer prognosis than patients with subsequent VTEs. There was a significant difference in overall survival (OS) between the presence and absence of a concurrent classic VTE diagnosis (median: OS, 2.1 mo vs. 10.7 mo; P<0.001). Even when VTE included SVT, the result was similar (P<0.001).
In Korean patients with advanced pancreatic cancer, the incidence of VTEs is comparable to that of Caucasian patients. We also found that pancreatic cancer patients with concurrent VTEs had a poor prognosis compared to patients who developed VTEs later.
Keywords: Korean, Advanced pancreatic cancer, Venous thromboembolism


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