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Blood Res 2017; 52(4):

Published online December 31, 2017

https://doi.org/10.5045/br.2017.52.4.334

© The Korean Society of Hematology

Comparison of the acute erythropoietic capacities of erythropoietin and U-74389G in terms of hemoglobin levels

Constantinos Tsompos1*, Constantinos Panoulis2, Konstantinos Toutouzas3, Aggeliki Triantafyllou4, George C Zografos3, and Apostolos Papalois5

Author Info. +

1Department of Gynecology, General Hospital of Thessaloniki “St. Dimitrios”, Thessaloniki, Greece.

2Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University, Athens, Greece.

3Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Greece.

4Department of Biologic Chemistry, Athens University, Athens, Greece.

5Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Greece.

Correspondence to : Constantinos Tsompos. Department of Gynecology, General Hospital of Thessaloniki “St. Dimitrios”, 2 Elenis Zografou Street, Thessaloniki 54634, Greece. Tsomposconstantinos@gmail.com

Received: November 21, 2016; Revised: April 9, 2017; Accepted: May 25, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

TABLES

Go to
Table. 1.The percent (%) augmentation influence of both drugs versus reoxygenation time.
Table. 2.U-74389G/erythropoietin efficacy ratios according to hemoglobin levels augmentation after chi-square tests application.
Table. 3.A U-74389G/erythropoietin efficacies ratios meta-analysis on 9 hematologic variableς (7 variables with balancing efficacies and 2 variables with opposite efficacies) [<span class="xref"><a href="#B15">15</a></span>].

REFERENCES

Go to
  1. Tsompos, C, Panoulis, C, Toutouzas, K, Zografos, G, Papalois, A. The effect of the antioxidant drug “U-74389G” on haemoglobin levels following a hypoxemia/re-oxygenation protocol in rats. J Crit Care Med, 2015;1;102-106.
  2. Tsompos, C, Panoulis, C, Toutouzas, K, Zografos, G, Papalois, A. The short-term effect of erythropoietin on hemoglobin during ischemia reperfusion injury in rats. Fiziologia, 2013;23;26-32.
  3. Himmelfarb, J, Ikizler, TA, Ellis, C, et al. Provision of antioxidant therapy in hemodialysis (PATH): a randomized clinical trial. J Am Soc Nephrol, 2014;25;623-633.
    Pubmed
  4. Jilani, T, Iqbal, MP. Does vitamin E have a role in treatment and prevention of anemia. Pak J Pharm Sci, 2011;24;237-242.
    Pubmed
  5. Martinez, Mdel, Afonso, SG, Meiss, RP, Buzaleh, AM, Batlle, A. Hepatic damage and oxidative stress induced by Griseofulvin in mice. Cell Mol Biol (Noisy-le-grand), 2009;55;127-139.
    Pubmed
  6. Prats, M, Font, R, García, C, et al. Oxidative stress markers in predicting response to treatment with ferric carboxymaltose in nondialysis chronic kidney disease patients. Clin Nephrol, 2014;81;419-426.
    Pubmed
  7. Martinez Mdel, C, Afonso, SG, Buzaleh, AM, Batlle, A. Protective action of antioxidants on hepatic damage induced by griseofulvin. ScientificWorldJournal, 2014;2014;982358.
    Pubmed
  8. Goldstein, BD, Harber, LC. Erythropoietic protoporphyria: lipid peroxidation and red cell membrane damage associated with photohemolysis. J Clin Invest, 1972;51;892-902.
    Pubmed
  9. Arslantaş, MK, Arslantaş, R, Tozan, EN. Effects of systemic erythropoietin on ischemic wound healing in rats. Ostomy Wound Manage, 2015;61;28-33.
  10. Khodosovskiĭ, MN, Zinchuk, VV. Erythropoietin influence on the blood oxygen transport and prooxidant-antioxidant state during hepatic ischemia-reperfusion. Ross Fiziol Zh Im I M Sechenova, 2014;100;592-601.
    Pubmed
  11. Kalantzi, M, Kalliakmani, P, Papachristou, E, et al. Parameters influencing blood erythropoietin levels of renal transplant recipients during the early post-transplantation period. Transplant Proc, 2014;46;3179-3182.
    Pubmed
  12. Hernández-Navarrete, LS, Hernández-Jiménez, JD, Jiménez-López, LA, Budar-Fernández, LF, Méndez-López, MT, Martínez-Mier, G. Experience in kidney transplantation without blood transfusion: kidney transplantation transfusion-free in Jehovah's Witnesses. First communication in Mexico. Cir Cir, 2013;81;450-453.
    Pubmed
  13. Zabaneh, R, Roger, SD, El-Shahawy, M, et al. Peginesatide to manage anemia in chronic kidney disease patients on peritoneal dialysis. Perit Dial Int, 2015;35;481-489.
    Pubmed
  14. Bartnicki, P, Kowalczyk, M, Rysz, J. The influence of the pleiotropic action of erythropoietin and its derivatives on nephroprotection. Med Sci Monit, 2013;19;599-605.
    Pubmed
  15. Tsompos, C, Panoulis, C, Toutouzas, K, Triantafyllou, A, Zografos, GC, Papalois, A. Comparison of the attenuating capacities of erythropoietin and U-74389G concerning blood platelet counts. J Sci Achiev, 2017;2;18-21.

Article

Letter to the Editor

Blood Res 2017; 52(4): 334-337

Published online December 31, 2017 https://doi.org/10.5045/br.2017.52.4.334

Copyright © The Korean Society of Hematology.

Comparison of the acute erythropoietic capacities of erythropoietin and U-74389G in terms of hemoglobin levels

Constantinos Tsompos1*, Constantinos Panoulis2, Konstantinos Toutouzas3, Aggeliki Triantafyllou4, George C Zografos3, and Apostolos Papalois5

1Department of Gynecology, General Hospital of Thessaloniki “St. Dimitrios”, Thessaloniki, Greece.

2Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University, Athens, Greece.

3Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Greece.

4Department of Biologic Chemistry, Athens University, Athens, Greece.

5Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Greece.

Correspondence to:Constantinos Tsompos. Department of Gynecology, General Hospital of Thessaloniki “St. Dimitrios”, 2 Elenis Zografou Street, Thessaloniki 54634, Greece. Tsomposconstantinos@gmail.com

Received: November 21, 2016; Revised: April 9, 2017; Accepted: May 25, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    The percent (%) augmentation influence of both drugs versus reoxygenation time.
    U-74389G/erythropoietin efficacy ratios according to hemoglobin levels augmentation after chi-square tests application.
    A U-74389G/erythropoietin efficacies ratios meta-analysis on 9 hematologic variableς (7 variables with balancing efficacies and 2 variables with opposite efficacies) [<span class="xref"><a href="#B15">15</a></span>].

    References

    1. Tsompos, C, Panoulis, C, Toutouzas, K, Zografos, G, Papalois, A. The effect of the antioxidant drug “U-74389G” on haemoglobin levels following a hypoxemia/re-oxygenation protocol in rats. J Crit Care Med, 2015;1;102-106.
    2. Tsompos, C, Panoulis, C, Toutouzas, K, Zografos, G, Papalois, A. The short-term effect of erythropoietin on hemoglobin during ischemia reperfusion injury in rats. Fiziologia, 2013;23;26-32.
    3. Himmelfarb, J, Ikizler, TA, Ellis, C, et al. Provision of antioxidant therapy in hemodialysis (PATH): a randomized clinical trial. J Am Soc Nephrol, 2014;25;623-633.
      Pubmed
    4. Jilani, T, Iqbal, MP. Does vitamin E have a role in treatment and prevention of anemia. Pak J Pharm Sci, 2011;24;237-242.
      Pubmed
    5. Martinez, Mdel, Afonso, SG, Meiss, RP, Buzaleh, AM, Batlle, A. Hepatic damage and oxidative stress induced by Griseofulvin in mice. Cell Mol Biol (Noisy-le-grand), 2009;55;127-139.
      Pubmed
    6. Prats, M, Font, R, García, C, et al. Oxidative stress markers in predicting response to treatment with ferric carboxymaltose in nondialysis chronic kidney disease patients. Clin Nephrol, 2014;81;419-426.
      Pubmed
    7. Martinez Mdel, C, Afonso, SG, Buzaleh, AM, Batlle, A. Protective action of antioxidants on hepatic damage induced by griseofulvin. ScientificWorldJournal, 2014;2014;982358.
      Pubmed
    8. Goldstein, BD, Harber, LC. Erythropoietic protoporphyria: lipid peroxidation and red cell membrane damage associated with photohemolysis. J Clin Invest, 1972;51;892-902.
      Pubmed
    9. Arslantaş, MK, Arslantaş, R, Tozan, EN. Effects of systemic erythropoietin on ischemic wound healing in rats. Ostomy Wound Manage, 2015;61;28-33.
    10. Khodosovskiĭ, MN, Zinchuk, VV. Erythropoietin influence on the blood oxygen transport and prooxidant-antioxidant state during hepatic ischemia-reperfusion. Ross Fiziol Zh Im I M Sechenova, 2014;100;592-601.
      Pubmed
    11. Kalantzi, M, Kalliakmani, P, Papachristou, E, et al. Parameters influencing blood erythropoietin levels of renal transplant recipients during the early post-transplantation period. Transplant Proc, 2014;46;3179-3182.
      Pubmed
    12. Hernández-Navarrete, LS, Hernández-Jiménez, JD, Jiménez-López, LA, Budar-Fernández, LF, Méndez-López, MT, Martínez-Mier, G. Experience in kidney transplantation without blood transfusion: kidney transplantation transfusion-free in Jehovah's Witnesses. First communication in Mexico. Cir Cir, 2013;81;450-453.
      Pubmed
    13. Zabaneh, R, Roger, SD, El-Shahawy, M, et al. Peginesatide to manage anemia in chronic kidney disease patients on peritoneal dialysis. Perit Dial Int, 2015;35;481-489.
      Pubmed
    14. Bartnicki, P, Kowalczyk, M, Rysz, J. The influence of the pleiotropic action of erythropoietin and its derivatives on nephroprotection. Med Sci Monit, 2013;19;599-605.
      Pubmed
    15. Tsompos, C, Panoulis, C, Toutouzas, K, Triantafyllou, A, Zografos, GC, Papalois, A. Comparison of the attenuating capacities of erythropoietin and U-74389G concerning blood platelet counts. J Sci Achiev, 2017;2;18-21.
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